Which root canal medicine (Bioceramic and calcium hydroxide) works better to reduce pain between visits

Comparative Efficacy of Bioceramic and Calcium Hydroxide Intracanal Medicaments on Interappointment Pain Reduction in Primary Non-surgical Endodontic therapy of non-vital posterior teeth- A Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/104621

Enrollment

140

Registered

2026-02-24

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K041- Necrosis of pulp

Interventions

Intervention1: Bio C Temp, Angelus, Brazil: Bioceramic intracanal medicament Control Intervention1: CalciCure, SafeEndo, India: Calcium Hydroxide intracanal medicament

Eligibility

Inclusion criteria

Inclusion criteria: Permanent posterior teeth with clinical signs of pulp necrosis Permanent posterior teeth with PAI score greater than or equal to 3 Patients willing to provide informed consent

Exclusion criteria

Exclusion criteria: Patients showing positive response to pulp sensibility test Patients with uncontrolled systemic disease, tooth mobility, root fractures,non restorable teeth,perforations,retreatment cases patients who had taken analgesics and antibiotics within the last 4-8 hours of treatment

Design outcomes

Primary

Measure	Time frame
Pain will be assessed using VAS scoreTimepoint: 4 hours, 12 hours, 24 hours, 3rd day, 7th day	—

Secondary

Measure	Time frame
Proportion of patients experiencing flare-ups will be assessedTimepoint: 4 hours, 12 hours, 24 hours, 3rd day and 7th day	—

Countries

India

Contacts

Public ContactDr BINU P

Government Dental College Thiruvananthapuram

drsreejamdas@gmail.com9446551581

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026