A Study Comparing Two Pain Relieving Add on Medicines with Local Anaesthetic for Numbing the Arm During Upper Limb Surgeries

Comparative Clinical Study Of Dexmedetomidine And Clonidine As Adjuvants To Levobupivacaine In Supraclavicular Brachial Plexus Block In Upper Limb Surgeries. - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/104595

Enrollment

Registered

2026-02-24

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Supraclavicular block: Supraclavicular brachial plexus block will be performed for providing anaesthesia and analgesia for upper limb surgeries. Control Intervention1: Levobupivacaine w

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anaesthesiologists physical status 1 and 2 Body Mass Index less than 30 kg per m2.

Exclusion criteria

Exclusion criteria: History of allergy to study drug. Infection at the site of injection. Coagulopathies. Patients on Beta blockers. Neurological deficit in the operating arm. Patients on anti psychotic and anti epileptic drugs. Patient not willing to participate.

Design outcomes

Primary

Measure	Time frame
To evaluate efficacy of Dexmedetomidine as an adjuvant to 0.5% Levobupivacaine versus Clonidine with 0.5% Levobupivacaine in Ultrasound-Guided Supraclavicular Brachial Plexus Block for Upper Limb Surgeries in terms of 1.Onset of sensory blockade . 2.Onset of motor blockade. 3.Duration of sensory blockade 4.Duration of motor blockade. 5.Intensity of motor blockade.Timepoint: Time of completion of injection of local anaesthetic will be labelled as 0 minutes After the block performance assessment of onset and duration of sensory block will be done by loss of sensation of pin prick onset and duration of motor block assessment will be done by bromage scale. Assessment of sensory and motor blockage will be done every 5 mins post block performance till 30 mins and then at an interval of 1 hr post surgery till the first 12 hrs and until the block had worn off completely. Assessment of intensity of motor blockade will be assessed every 5 mins till grade 3 motor block is achieved.	—

Measure

Time frame

To evaluate efficacy of Dexmedetomidine as an adjuvant to 0.5% Levobupivacaine versus Clonidine with 0.5% Levobupivacaine in Ultrasound-Guided Supraclavicular Brachial Plexus Block for Upper Limb Surgeries in terms of 1.Onset of sensory blockade . 2.Onset of motor blockade. 3.Duration of sensory blockade 4.Duration of motor blockade. 5.Intensity of motor blockade.Timepoint: Time of completion of injection of local anaesthetic will be labelled as 0 minutes After the block performance assessment of onset and duration of sensory block will be done by loss of sensation of pin prick onset and duration of motor block assessment will be done by bromage scale. Assessment of sensory and motor blockage will be done every 5 mins post block performance till 30 mins and then at an interval of 1 hr post surgery till the first 12 hrs and until the block had worn off completely. Assessment of intensity of motor blockade will be assessed every 5 mins till grade 3 motor block is achieved.

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Secondary

Measure	Time frame
To evaluate postoperative analgesia with Dexmedetomidine as an adjuvant to 0.5% Levobupivacaine versus Clonidine with 0.5% Levobupivacaine in Ultrasound-Guided Supraclavicular Brachial Plexus Block for Upper Limb Surgeries in terms of 1.Visual analogue score for pain assessment. 2.Time for requirement of first rescue analgesia. 3.Total analgesic requirement in 24 hours. 4.Complications like Hypotension , Bradycardia , Sedation.Timepoint: Time of completion of injection of local anaesthetic will be labelled as 0 minutes. Visual Analog Score will be assessed immediately post operatively Total rescue analgesia will be assessed in 24 hours Hemodynamic parameters and sedation will be monitored every 5 mins for first 30 mins and then every 30 mins for the rest of the surgery.	—

Measure

Time frame

To evaluate postoperative analgesia with Dexmedetomidine as an adjuvant to 0.5% Levobupivacaine versus Clonidine with 0.5% Levobupivacaine in Ultrasound-Guided Supraclavicular Brachial Plexus Block for Upper Limb Surgeries in terms of 1.Visual analogue score for pain assessment. 2.Time for requirement of first rescue analgesia. 3.Total analgesic requirement in 24 hours. 4.Complications like Hypotension , Bradycardia , Sedation.Timepoint: Time of completion of injection of local anaesthetic will be labelled as 0 minutes. Visual Analog Score will be assessed immediately post operatively Total rescue analgesia will be assessed in 24 hours Hemodynamic parameters and sedation will be monitored every 5 mins for first 30 mins and then every 30 mins for the rest of the surgery.

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Countries

India

Contacts

Public ContactDr Ajeet Jyotipurkar

NKP Salve Institute of Medical Sciences and Research Centre and Lata Mangeshkar Hospital Nagpur

ajeet.jyotipurkar@gmail.com9561306782

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026