Health Condition 1: E039- Hypothyroidism, unspecified
Conditions
Interventions
Intervention1: Enhanced Thyroid Screening During Pregnancy: Pregnant women will undergo enhanced thyroid screening with serum Thyroid Stimulating Hormone and Free Thyroxine testing in each trimester.
Sponsors
ICMR
Eligibility
Inclusion criteria
Inclusion criteria: Pregnant women aged 18 to 45 years attending antenatal clinics in Telangana. Women in early pregnancy up to twelve weeks of gestation with singleton pregnancy who are willing to provide written informed consent and participate in follow up visits will be included.
Exclusion criteria
Exclusion criteria: Women with known thyroid disease currently on treatment. Women with multiple pregnancy. Women with severe chronic medical illness requiring long term medication. Women who are unable or unwilling to provide informed consent or comply with study procedures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of pregnant women identified with hypothyroidism including overt and subclinical hypothyroidism through enhanced thyroid screening compared with standard Thyroid Stimulating Hormone only screeningTimepoint: Baseline,18-22 weeks,28-32 weeks of gestation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Prevalence of iodine, iron, selenium, zinc and vitamin D deficiencies in early pregnancy and their association with thyroid dysfunctionTimepoint: At baseline assessment in the first trimester at enrolment;Incidence of adverse pregnancy outcomes including preterm birth, low birth weight, gestational diabetes mellitus and hypertensive disorders of pregnancy among women with thyroid dysfunctionTimepoint: Assessed at delivery and immediate postpartum period | — |
Countries
India
Contacts
Public ContactDr CHILUMULA MONICA
ICMR-NIN
Outcome results
None listed