Effect of Body Position on Breathing in Adults Undergoing Brain Surgery Using a Non-Invasive Lung Monitoring Method.

Regional ventilation distribution in adult patients undergoing neurosurgical procedures in different positions - a prospective interventional study using electrical impedance tomography. - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/104549

Enrollment

Registered

2026-02-23

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G938- Other specified disorders of brain

Interventions

Intervention1: Pressure controlled ventilation: Zero and Five PEEP will be applied each for 5 minutes. Control Intervention1: Volume controlled ventilation mode: Zero and Five PEEP will be applied for

Eligibility

Inclusion criteria

Inclusion criteria: PATIENTS UNDERGOING ELECTIVE NEUROSURGERY UNDER GENERAL ANAESTHESIA

Exclusion criteria

Exclusion criteria: 1. Refusal of consent 2. Patients with an endotracheal tube in situ prior to the planned surgical procedure 3. Pregnancy 4. Patients with cardiac failure, cardiac pacemakers, etc. 5. Obese patients (BMI more than 30) 6. At risk of aspiration poor GCS, bulbar palsy 7. Patients with known respiratory disease pleural effusion, pneumothorax, COPD, Asthma, pneumonia, emphysematous bulla.

Design outcomes

Primary

Measure	Time frame
To determine the changes in EIT parameters - global inhomogeneity index (GII), Anterior/Posterior ratio (A/P ratio), and Respiratory ventilation delay (RVD) in adult neurosurgical patients undergoing surgery in supine, lateral and prone positions. To compare the EIT parameters - global inhomogeneity index (GII), Anterior/Posterior ratio (A/P ratio), and Respiratory ventilation delay (RVD) changes with volume and pressure-controlled ventilation. Timepoint: At basline, after induction, after positioning, every 5 minutes for 1 hour.	—

Measure

Time frame

To determine the changes in EIT parameters - global inhomogeneity index (GII), Anterior/Posterior ratio (A/P ratio), and Respiratory ventilation delay (RVD) in adult neurosurgical patients undergoing surgery in supine, lateral and prone positions. To compare the EIT parameters - global inhomogeneity index (GII), Anterior/Posterior ratio (A/P ratio), and Respiratory ventilation delay (RVD) changes with volume and pressure-controlled ventilation. Timepoint: At basline, after induction, after positioning, every 5 minutes for 1 hour.

—

Secondary

Measure	Time frame
To compare the EIT parameters - global inhomogeneity index (GII), Anterior/Posterior ratio (A/P ratio), and Respiratory ventilation delay (RVD) changes with PEEP zero and 5 cmH2O in both ventilation modes. To correlate the EIT paramters - global inhomogeneity index (GII), Anterior/Posterior ratio (A/P ratio), and Respiratory ventilation delay (RVD) changes with changes in driving pressure and lung compliance. Timepoint: - At baseline before induction - After Intubation in supine flat position 5 Min - In final position (5 min recording each) o VCV0 Volume controlled ventilation at PEEP of 0 cmH2O o VCV5 Volume controlled ventilation at PEEP of 5 cmH2O o PCV0 Pressure controlled ventilation at PEEP of 0 cmH2O o PCV5 Pressure controlled ventilation at PEEP of 5 cmH2O	—

Measure

Time frame

To compare the EIT parameters - global inhomogeneity index (GII), Anterior/Posterior ratio (A/P ratio), and Respiratory ventilation delay (RVD) changes with PEEP zero and 5 cmH2O in both ventilation modes. To correlate the EIT paramters - global inhomogeneity index (GII), Anterior/Posterior ratio (A/P ratio), and Respiratory ventilation delay (RVD) changes with changes in driving pressure and lung compliance. Timepoint: - At baseline before induction - After Intubation in supine flat position 5 Min - In final position (5 min recording each) o VCV0 Volume controlled ventilation at PEEP of 0 cmH2O o VCV5 Volume controlled ventilation at PEEP of 5 cmH2O o PCV0 Pressure controlled ventilation at PEEP of 0 cmH2O o PCV5 Pressure controlled ventilation at PEEP of 5 cmH2O

—

Countries

India

Contacts

Public ContactBharath S

National Institute of Mental Health And Neuro Sciences,P.B.NO.2900, Hosur Road, Bengaluru

bharathvinay@gmail.com9945965202

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026