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Management of Infective Keratitis in Rural Bihar.

Epidemiology of Infective Keratitis in Rural Bihar with Integrated Omics and AI-Based Approaches for Diagnosis and Prognosis - NIL

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/02/104526
Enrollment
410
Registered
2026-02-23
Start date
Unknown
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H160- Corneal ulcer

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil Intervention4: Nil: Nil Intervention5: Nil: Nil Intervention6: Nil: Nil

Sponsors

Akhand Jyoti Eye Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Confirmed diagnosis of infective keratitis defined by the presence of corneal epithelial or stromal infiltration with associated ocular inflammation, verified clinically by slit lamp examination. 2. Age greater than 5 years (pediatric and adult populations eligible). 3. Presentation within 4-8 weeks of symptom onset, enabling adequate microbiology sampling and microbiological characterization. 4. Residence in the study hospitals catchment area or agreement to attend follow-up visits. 5. Willingness to participate in microbiological sampling, molecular diagnostics, and omics analysis including tear fluid collection like corneal scraping or tear sample or optional blood sample. 6. Control- Normal tear sample will be included as a control group for comparison.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Establishment of the epidemiology of infective keratitis in rural Bihar and development of an integrated AI omics-based diagnostic and prognostic framework using clinical, imaging, microbiological, and molecular data.Timepoint: 0,6,10,12 months—

Secondary

MeasureTime frame
1. Identification of demographic patterns, risk factors, & microbiological spectrum of infective keratitis using conventional culture & molecular sequencing. 2. Discovery of genomic & proteomic biomarkers (virulence markers, antimicrobial resistance, & prognostic signatures) from pathogen isolates & patient samples. 3. Development of a curated multimodal dataset & generation of validated analytical outputs including AI model performance, interim analysis, & publication-ready results.Timepoint: 10,14,16 months—

Countries

India

Contacts

Public ContactDr Md Afroz Alam

akhand Jyoti Eye Hospital

draniket@akhandjyoti.org7903792016

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026