Checking if the gums react differently to two types of dental crowns PEEK and zirconia by measuring IL1beta,a substance linked to inflammation."

COMPARATIVE EVALUATION OF IL-1 beta LEVELS IN GINGIVAL CREVICULAR FLUID AROUND CAD - CAM FABRICATED PEEK CROWNS AND POLISHED ZIRCONIA CROWNS - AN IN VIVO STUDY - nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/104522

Enrollment

Registered

2026-02-23

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: PEEK CROWN: To evaluate the level of IL-1 beta in gingival crevicular fluid (GCF) before before tooth preparation (baseline) and after the cementation of full coverage of PEEK crown on

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients requiring bilaterally posterior mandibular complete crowns. Teeth selected for Permanent CAD/CAM crowns preparation should be restorable with a minimum crown to root ratio of at least 1:1. 2. Patients with good oral hygiene and periodontal status. 3. Patients with full complement of teeth (excluding 3rd molars). 4. Patients who will be available for the required follow up period. 5. Patients giving positive informed consent. 6. Patients with plaque index less than 15 percent, bleeding index less than 10 percent.

Exclusion criteria

Exclusion criteria: 1. Patients with developmental defects of enamel and dentin. 2.Patients with systemic disease (e.g, diabetic mellitus, hypertension, cancer, Sjogren s syndrome etc.) 3. Habitual tobacco smokers. 4. Untreated gingival or periodontal disease 5. Parafunctional habits like bruxism, clenching.

Design outcomes

Primary

Measure	Time frame
To evaluate and compare the effect of PEEK crown and polished zirconia crown on IL-1 beta levels in gingival crevicular fluid (GCF) on mandibular posterior teeth on both side.Timepoint: to evaluate and compare IL1Beta at baseline,1 month and 3 month after tooth prepration.	—

Secondary

Measure	Time frame
NilTimepoint: Nil	—

Countries

India

Contacts

Public ContactTadu konya

All india institute of medical sciences

drarunaiimsdelhi@gmaill.com9985203202

Outcome results