A study comparing two medicines to find out which one better stops shivering after spinal anesthesia.

A Randomized ,double blind Clinical trial comparing the efficacy of Intravenous Pethidine and Ketamine in Treating Post-Spinal Shivering - nil

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/104521

Enrollment

Registered

2026-02-23

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Intravenous pethidine: Time taken for IV pethidine for cessation of shivering intraoperatively post spinal anesthesia. Control Intervention1: Intravenous ketamine: Time taken for IV ket

Eligibility

Inclusion criteria

Inclusion criteria: ASA Grade I II. patient undergoing lower limb and lower abdominal surgeries. Patients developing Grade 2 or higher grade shivering (according to Wrench Scale) post spinal anesthesia. Ability to provide informed consent.

Exclusion criteria

Exclusion criteria: Known hypersensitivity to any of the study drugs. patients refusing consent. Patients with neurological or psychiatric disorders, seizure history . Patients on antidepressants or antiepileptics. Patients with temperature regulation disorders. thyroid dysfunction, baseline fever, neuromuscular disorders. pregnancy.

Design outcomes

Primary

Measure	Time frame
To compare the efficacy of intravenous pethidine and ketamine in treating post-spinal shivering intraoperatively in the cessation of shivering in patients undergoing lower limb and lower abdominal surgeries.Timepoint: patient monitored after the onset of shivering ,post spinal anesthesia and after giving treatment with one of the group, vitals and grade of shivering noted at 0 min, 5 min , 10 min and later each 10 mins till shivering stops and patient monitored for recurrences of shivering till surgery gets completed and shifted to postoperative care.	—

Measure

Time frame

To compare the efficacy of intravenous pethidine and ketamine in treating post-spinal shivering intraoperatively in the cessation of shivering in patients undergoing lower limb and lower abdominal surgeries.Timepoint: patient monitored after the onset of shivering ,post spinal anesthesia and after giving treatment with one of the group, vitals and grade of shivering noted at 0 min, 5 min , 10 min and later each 10 mins till shivering stops and patient monitored for recurrences of shivering till surgery gets completed and shifted to postoperative care.

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Secondary

Measure	Time frame
To assess the time taken to cessation of shivering after administration of each drug.Timepoint: 0 min and 5 mins once till cessation of shivering.;To compare the Differences in reduction in grading of shivering.Timepoint: according to wrench scale, grade of shivering reduced below 2.;To assess the recurrence of shivering after treatment with each drug.Timepoint: patient monitored till the end of surgery for recurrences of shivering.;To evaluate the side effects associated with pethidine and ketamine.Timepoint: side effects are treated accordingly.	—

Measure

Time frame

To assess the time taken to cessation of shivering after administration of each drug.Timepoint: 0 min and 5 mins once till cessation of shivering.;To compare the Differences in reduction in grading of shivering.Timepoint: according to wrench scale, grade of shivering reduced below 2.;To assess the recurrence of shivering after treatment with each drug.Timepoint: patient monitored till the end of surgery for recurrences of shivering.;To evaluate the side effects associated with pethidine and ketamine.Timepoint: side effects are treated accordingly.

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Countries

India

Contacts

Public ContactDr merlin shalini ruth

chettinad hospital and research institute

merlin5shalini@gmail.com9790983957

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026