Health Condition 1: K026- Dental caries on smooth surface
Conditions
Interventions
Intervention1: Nil: Nil
Control Intervention1: Cathelicidin LL-37 and HNP- 3: comparison between salivary levels of Calthelicidin LL -37 and HNP -3 in caries free and early childhood caries children
Sponsors
Dr CHINMAYA G J
Eligibility
Inclusion criteria
Inclusion criteria: Children of 3-6 years of age. Children with 4 and more than 4 active carious lesions ( Experimental group) Children with no caries ( Control group ) Parents giving consent for the study.
Exclusion criteria
Exclusion criteria: Children who received fluoride topical application during the last 1 month. Children requiring special health care needs. Pulpally involved teeth. Children who were on antibiotic therapy within the past 3 months. Children with genetic diseases or syndromes. Children on any medications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the salivary cathelicidin LL-37 and Human neutrophil peptide 3 [HNP-3] activity in caries active and caries free children using Reverse transcription Polymerase Chain reaction [RT- PCR].Timepoint: 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| To correlate the activity of cathelicidin LL-37 and Human neutrophil peptide 3 [HNP-3] in terms of age, gender and number of caries in caries active and caries free children. To determine the association between salivary LL-37, HNP-3 and mutans streptococci, S sorbinus and severe early childhood caries. Timepoint: 6 months | — |
Countries
India
Contacts
Public ContactDr CHINMAYA G J
Rajarajeswari Dental College and Hospital
Outcome results
None listed