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Locally delivered agents in chronic periodontitis

Comparative evaluation of ozonated olive oil gelatin film and ozonated olive oil chitosan film as local drug delivery systems adjunct to scaling and root planing in management of patients with chronic periodontitis: A split-mouth randomized clinical trial. - NIL

Status
Active, not recruiting
Phases
Phase 3Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/02/104465
Enrollment
30
Registered
2026-02-20
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: ozonated olive oil chitosan film: 15 sites in patients undergoing scaling and root planing will be administered with Ozonated olive oil chitosan film inserted deep into the periodontal

Sponsors

Varshini S
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Systemically healthy males and females participants of 25-55 years having 20 teeth or more except third molars having Chronic Periodontitis with at least one pocket in each quadrant with periodontal pockets depth measuring more than or equal to 5 mm and clinical attachment level more than or equal to 1 mm.

Exclusion criteria

Exclusion criteria: Pregnant and lactating women. Patients with systemic disease. Patients who have had antibiotics, nonsteroidal anti-inflammatory medications, or corticosteroids in the preceding six month. Patients who had received periodontal treatment in the past six months. Patients allergic to gelatin or chitosan or ozonated olive oil.

Design outcomes

Secondary

MeasureTime frame
Semi quantification of p.gingivalis by conventional PCR(Microbiological parameter)Timepoint: Baseline , 3 month

Primary

MeasureTime frame
Probing pocket depth, Clinical attachment level,Plaque index (PI) (Silness and Loe 1964),Gingival index (GI) (Loe and Silness 1963)Timepoint: Baseline, 1 month, 3 month

Countries

India

Contacts

Public ContactVarshini S

Sri Rajiv Gandhi College of Dental Sciences and Hospital

umeshyadalam@gmail.com08197504672

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026