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Study to evaluate the relationship between Ki-67 protein expression and cell division rate in oral cancer

Correlation between ki67 labelling index and mitotic index in Oral squamous cell carcinoma - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/02/104463
Enrollment
75
Registered
2026-02-20
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C069- Malignant neoplasm of mouth, unspecified

Interventions

Intervention1: Nil: Nil Intervention2: Not applicable: Nil

Sponsors

Datta Meghe Medical College, Datta Meghe Institute of Higher Education and Research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Well-fixed, properly stained tissue blocks with a histopathologically confirmed diagnosis of OSCC. 2.All operated cases of OSCC. 3.All patients with Denovo- arising OSCC. 4.All cases with Composite resection of lesion + suitable modified radical neck dissection (MRND) + reconstruction with microvascular flap

Exclusion criteria

Exclusion criteria: 1. Every instance of cancer except OSCC. 2. All cases of lesions in the oral cavity that are not neoplastic. 3. Insufficient, necrotic, or autolyzed biopsy specimens. 4. Recurrence cases. 5. Patients who have previously received radiation and chemotherapy

Design outcomes

Primary

MeasureTime frame
Correlation between Ki-67 labelling index (%) and mitotic index (number of mitoses per 1000 tumour cells) in oral squamous cell carcinoma tissueTimepoint: At the time of histopathological and immunohistochemical evaluation of tumour specimen (baseline, single time point)—

Secondary

MeasureTime frame
Association of Ki-67 labelling index with histopathological grade of oral squamous cell carcinoma.Timepoint: Baseline (at time of IHC evaluation);Association of mitotic index with histopathological grade of oral squamous cell carcinoma.Timepoint: Baseline (at time of histopathological examination);Comparison of Ki-67 labelling index and mitotic index across different grades of OSCC.Timepoint: Baseline;Association of Ki-67 labelling index and mitotic index with clinicopathological parameters.Timepoint: Baseline—

Countries

India

Contacts

Public ContactDr Dhairya Majethia

Datta Meghe Medical College, Datta Meghe Institute of Higher Education and Research

mpande350@gmail.com9422802512

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026