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Comparison of two routes of drug Dexmedetomidine used for hypotensive anaesthesia during FESS Surgery in adults

Comparison of Nebulized versus intravenous Dexmedetomidine for hypotensive anaesthesia during functional endoscopic sinus nasal surgery in adults - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/02/104427
Enrollment
50
Registered
2026-02-20
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J349- Unspecified disorder of nose and nasal sinuses

Interventions

Intervention1: Nebulized Dexmedetomidine: Dexmedetomidine is given as nebulization at 1mcg per kg 15min before induction Control Intervention1: Intravenous Dexmedetomidine: Dexmedetomidine is given in

Sponsors

MDM hospital, Dr. SN medical College jodhpur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Adult patients aged 18 and above years of either sex. 2. ASA physical status I or II individuals 3. Patients undergoing elective FESS under general anaesthesia (operative duration of 60-120 minutes). 4. Patients must be able to provide written informed consent and must have no contraindications to the use of dexmedetomidine through either nebulized or intravenous routes.

Exclusion criteria

Exclusion criteria: Refusal of consent by the patient. 2. Patients known hypersensitivity to dexmedetomidine. 3. Patient with significant cardiovascular instability. 4. Pregnant or lactating women. 5. Patients with hepatic, renal, neurologic, or psychiatric disorders that may interfere with drug metabolism or study assessments will not be included

Design outcomes

Primary

MeasureTime frame
The primary objective of this study is to assess the incidence of hypotension in nebulized versus intravenous dexmedetomidine for hypotensive anaesthesia during FESS in adults.Timepoint: During the surgery at 5 min,10min, 15min,20min ,25min and till the end of anaesthesia—

Secondary

MeasureTime frame
The following objectives will be recorded & compared between nebulized & intravenous groups: 1. Mean arterial pressure & heart rate. 2. Intraoperative need for rescue medication for hypotension (Inj. Esmolol). 3. Intraoperative analgesics & opioid requirements. 4. Recovery parameters, including sedation levels using Ramsay Sedation Score, time to extubation, & time to discharge from PACU. 5. Incidence of adverse effects.Timepoint: At 5min,10min,15min,20min,25min,30min & till end of anaesthesia—

Countries

India

Contacts

Public ContactDr Sarita Janwaja

Dr SN medical College jodhpur

Sarita.janweja@gmail.com9829116420

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026