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A study comparing the pain relieving effects of two medicines, dexmedetomidine and lignocaine after keyhole gallbladder removal surgery in patients of age group from 18 to 65 years old. Also to assess the difference in the heart rate, blood pressure during surgery between the two drugs.

Comparison between the efficacy of intravenous dexmedetomidine vs intravenous lignocaine on post operative analgesia in patients undergoing laparoscopic cholecystectomy - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/02/104368
Enrollment
86
Registered
2026-02-20
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K804- Calculus of bile duct with cholecystitis

Interventions

Intervention1: Dexmedetomidine: Route of administration- intravenous dexmedetomidine Loading Dose- 1 g/kg IV Administered over 10 minutes Given once prior to induction of anesthesia Maintenance

Sponsors

Dr Manchala Jyothi Sai Reddy
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients aged 18 to 65 years of either sex with the American Society of Anesthesiologists physical status classes 1 and 2 undergoing elective laparoscopic cholecystectomy surgery.

Exclusion criteria

Exclusion criteria: 1)Patients unwilling to participate in the study. 2)Patients with BMI more than 35 kgm2 3)History of hypersensitivity to the drugs 4)Parturient 5)Chronic use of opioids or opioid addiction, steroids. 6)Inability to comprehend postoperatively for the pain assessment scale or neuropsychiatric disorders.

Design outcomes

Primary

MeasureTime frame
1) Duration of analgesia 2) VAS score Timepoint: Intraoperative assessment done at Baseline, After boluses of study drugs, Immediately after ETI, 5min, 15min, 30min, 45m, 1h, 1h15m, 1h30m, 1h45m, 2h, until the pneumoperitoneum is released. Postoperatively assessed at 1hr, 4hr, 8hr, 12hr, and upto 24 hours—

Secondary

MeasureTime frame
1) Intraoperative Hemodynamic parameters at baseline, after boluses of drugs administration, immediately after intubation, 5min & every 15min until the end of the procedure. 2) Side effects like nausea, vomiting & sore throat. 3) Early ambulation. 4) Patient satisfaction using surgical satisfaction questionnaire 8 (SSQ-8). Timepoint: Intraoperative assessment done at Baseline, After boluses of study drugs, Immediately after ETI, 5min, 15min, 30min, 45m, 1h, 1h15m, 1h30m, 1h45m, 2h, until the pneumoperitoneum is released. Postoperatively assessed at 1hr, 4hr, 8hr, 12hr, & upto 24hours—

Countries

India

Contacts

Public ContactManchala Jyothi Sai Reddy
Kavya.prabhu@manipal.edu

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026