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A study to compare healing after wisdom tooth removal using platelet concentrate (PRF) alone, PRF with gelfoam, and PRF with chitosan, using clinical examination and X-rays.

Comparative Clinical and Radiographic evaluation of PRF, PRF with Gelfoam and PRF with Chitosan in Mandibular Third Molar extraction socket healing - A Randomized Controlled Trial. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/02/104335
Enrollment
144
Registered
2026-02-19
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: PRF Clot: Randomization of participants into four groups will be carried out as per computer generated list of random numbers into group A, group B, group C and group D according to the

Sponsors

Nair Hospital Dental College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients aged 18- 40 years. 2. Patients with good general health (ASA I). 3. Patients requiring surgical extraction of mandibular third molars. (impacted, carious or, periodontally involved lower third molars indicating need for extraction) 4. Patients with adequate mouth opening to permit standard surgical access. 5. Patients willing to participate. 6. Patients willing to provide written informed consent. 7. Patients willing to comply with the study protocol and follow-up visits.

Exclusion criteria

Exclusion criteria: 1. Patients with systemic conditions affecting wound healing (uncontrolled diabetes mellitus, immunocompromised states). 2. Patients with bleeding disorders or platelet abnormalities. 3. Patients on anticoagulant or long-term steroid therapy. 4. Patients with active infection at the extraction site. 5. Smokers, alcoholics and tobacco users. 6. Pregnant or lactating women. 7. Patients allergic to local anesthetic agents. 8. Patients with previous surgery or pathology in the mandibular third molar region. 9. Mentally challenged patients or patients who are unable to communicate. 10. Patients unwilling to participate or unable to comply with follow-up visits.

Design outcomes

Primary

MeasureTime frame
1.Soft tissue healing (Modified Landry Healing Index) 2.Bone Regeneration (IOPA Xray using a Grid) Timepoint: Day 3 Day 7 Day 14 1 month 3 months—

Secondary

MeasureTime frame
1. Hemostasis 2. Post Operative Pain (VAS score) 3. Swelling 4. Trismus (Maximum Inter Incisal Distance) 5. Incidence of Dry Socket Timepoint: 30 mins & 60 mins post extraction for hemostasis. Day 1 Day 3 Day 7 Day 14 1 month 3 months—

Countries

India

Contacts

Public ContactDr Akshaya Chavan

Nair Hospital Dental College

tgandhewar@yahoo.com9819323729

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026