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Comparison of commonly used disinfecting solutions in root canal treatment

Comparative evaluation of chlorhexidine and antibiotic combination irrigants containing amoxyclav, ciprofloxacin and metronidazole for root canal disinfection An in vivo study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/02/104223
Enrollment
40
Registered
2026-02-18
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: Chlorhexidine+ Metronidazole Group: After standardized chemomechanical preparation, canals will be irrigated using a combination solution of 2% chlorhexidine and 0.5% metronidazole(5 ml

Sponsors

Dr Priya Naikwade
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Diagnosed with pulpal and peri radicular diseases. 2.Patients indicated for root canal treatment. 3.Patients willing to comply with Study protocol and Follow-up visits.

Exclusion criteria

Exclusion criteria: 1.Patients with Systemic diseases affecting immunity or wound healing 2.Patients with history of antibiotic intake within the previous 4 weeks. 3.Teeth with Previous root canal treatment, Open apex, immature roots, or incomplete root formation,Internal or external root resorption, Root fractures or cracks,Calcified canals or severely curved canals

Design outcomes

Primary

MeasureTime frame
Reduction in intracanal microbial load (expressed as colony forming units per milliliter, CFU/ml) from baseline to post-irrigation following use of chlorhexidine and antibiotic combination irrigants.Timepoint: Day 1—

Secondary

MeasureTime frame
Intergroup comparison of antimicrobial efficacy among chlorhexidine and antibiotic combination irrigants.Timepoint: Day 1—

Countries

India

Contacts

Public ContactDr Bharat Deosarkar

Saraswati Dhanwantari Dental college, Parbhani

deosarkar.bharat16@gmail.com9975581234

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026