A clinical trial on Dhadimathi Kashayam in the management of Raththa Piththam (Systemic Hypertension )

A prospective open labelled,single arm,non-randomized,single centric,phase II clinical trial to determine the effectiveness of Dhadimathi Kashayam in the management of Raththa Piththam(Systemic Hypertension) - Nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/104184

Enrollment

Registered

2026-02-18

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I10- Essential (primary) hypertension

Interventions

Intervention1: DHADIMATHI KASHAYAM: Dosage-50ml (Twice a day orally),before food for 48 days Control Intervention1: NIL: NIL

Eligibility

Inclusion criteria

Inclusion criteria: Known Systemic Hypertension High Normal (SBP 130-139 mmHg and/or DBP 85-89 mmHg) Grade 1 Hypertension (SBP 140-159 mmHg and/or DBP 90-99 mmHg) Grade 2 Hypertension (SBP 160-179 mmHg and/or DBP 100-109 mmHg)

Exclusion criteria

Exclusion criteria: Known Malignant hypertension Ischemic heart diseases Chronic kidney disease Chronic liver disease Malignancy Hyperlipidemia Diabetes mellitus Smoking and Alcoholism.

Design outcomes

Primary

Measure	Time frame
The outcome will be aimed at reducing systemic blood pressure. This will reduce the risk of developing complications from Hypertension. Patients will adhere to regular BP monitoring, medications and follow up appointments for Hypertension. The trial drug, DHADIMATHI KASHAYAM, will be justified for its potential effect in the clinical study of management of systemic hypertension. So the trail medicine will be safer to manage in systemic hypertension patients Timepoint: 48 days	—

Measure

Time frame

The outcome will be aimed at reducing systemic blood pressure. This will reduce the risk of developing complications from Hypertension. Patients will adhere to regular BP monitoring, medications and follow up appointments for Hypertension. The trial drug, DHADIMATHI KASHAYAM, will be justified for its potential effect in the clinical study of management of systemic hypertension. So the trail medicine will be safer to manage in systemic hypertension patients Timepoint: 48 days

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Secondary

Measure	Time frame
To collect various Siddha literatures and modern journals for literature review on RATHTHA PITHTHAM NOI. To study other cofactors related to disease like age, sex, dietary habits, family history, and socioeconomic status. To perform physicochemical,phytochemical,bio chemical analysis of DHADIMATHI KASHAYAM. To evaluate safety profile for acute and toxicity of DHADIMATHI KASHAYAM. To evaluate pharmacological activities of DHADIMATHI KASHAYAM. To perform molecular docking studies for ACE inhibitor and Angiotensin receptor blocker activities. To evaluate Siddha parameters (including Envagai thervu, Neerkuri-Neikuri) in RATHTHA PITHTHAM NOI during trial period. To evaluate modern parametric changes in RATHTHA PITHTHAM NOI. To document Bio statistical analysis. Timepoint: 06 MONTHS	—

Measure

Time frame

To collect various Siddha literatures and modern journals for literature review on RATHTHA PITHTHAM NOI. To study other cofactors related to disease like age, sex, dietary habits, family history, and socioeconomic status. To perform physicochemical,phytochemical,bio chemical analysis of DHADIMATHI KASHAYAM. To evaluate safety profile for acute and toxicity of DHADIMATHI KASHAYAM. To evaluate pharmacological activities of DHADIMATHI KASHAYAM. To perform molecular docking studies for ACE inhibitor and Angiotensin receptor blocker activities. To evaluate Siddha parameters (including Envagai thervu, Neerkuri-Neikuri) in RATHTHA PITHTHAM NOI during trial period. To evaluate modern parametric changes in RATHTHA PITHTHAM NOI. To document Bio statistical analysis. Timepoint: 06 MONTHS

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Countries

India

Contacts

Public ContactDR S JUSTUS ANTONY

Government Siddha Medical College and Hospital .

siddhadrgs21@gmail.com9345600723

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026