A clinical trial on pirappan kizhangu kudineer in the management of uthiravatha suronitham (Rheumatoid Arthritis )

A prospective open labelled, single arm, non-randomized, single centric, phase II clinical trial to determine the effectiveness of PIRAPPAN KIZHANGU KUDINEER in the management of UTHIRAVATHA SURONITHAM (RHEUMATOID ARTHRITIS) - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/104158

Enrollment

Registered

2026-02-18

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M059- Rheumatoid arthritis with rheumatoid factor, unspecified

Interventions

Intervention1: Pirappan kizhangu kudineer: Uthiravatha suronitham(Rheumatoid Arthritis) Intervention2: Pirappan kizhangu kudineer: 60 ml twice a day orally for 48 days Control Intervention1: NOT APPLI

Eligibility

Inclusion criteria

Inclusion criteria: 1.Pain and early morning stiffness more than one hour . 2.Those who are willing to participate in this study 3.RA Factor test positive 4.Anti CCP positive 5.CRP elevated 6.ESR elevated

Exclusion criteria

Exclusion criteria: 1.other degenerating joint diseases-osteoarthritis ,seronegative spondylo arthritis ,ankylosing spondylitis 2.Infectious joint diseases like tuberculosis,chronic poly arthritis in chickungunia viral infection 3.Metabolic joint diseases like gout . 4.patient who is on DMARD.(eg.methotrexate). 5.Pregnancy and lactating mother. 6.Chronic renal &liver diseases patients 7.Malignancy

Design outcomes

Primary

Measure	Time frame
The outcome will be aimed at reducing the symptoms of uthiravatha suronitham (Rheumatoid arthritis) and to determine the efficacy of Pirappan kizhangu kudineer.Timepoint: 48 days	—

Secondary

Measure	Time frame
1.To collect various siddha literatures & modern journalsfor literature review on Uthiravatha suronitham. 2.To perform physicochemical, phytochemical, biochemical analysis of Pirappan kizhangu kudineer. 3.To evaluate the safety profile for acute toxicity of Pirappan kizhangu kudineer. 4.To evaluate pharmacological activities of Pirappan kizhangu kudineer. 5.To evaluate other cofactorsrealeated to disease like age,sex,dietary habits,family history,& socioeconomic status . 6.To evaluate siddha parameters (including envagaithervu) in Uthiravatha suronitham during trial period. 7.To evaluate modern parametric changes. 8.To assess the quality of life of uthiravatha suronitham. 9.To document bio statistical analysis. Timepoint: 6 Months	—

Measure

Time frame

1.To collect various siddha literatures & modern journalsfor literature review on Uthiravatha suronitham. 2.To perform physicochemical, phytochemical, biochemical analysis of Pirappan kizhangu kudineer. 3.To evaluate the safety profile for acute toxicity of Pirappan kizhangu kudineer. 4.To evaluate pharmacological activities of Pirappan kizhangu kudineer. 5.To evaluate other cofactorsrealeated to disease like age,sex,dietary habits,family history,& socioeconomic status . 6.To evaluate siddha parameters (including envagaithervu) in Uthiravatha suronitham during trial period. 7.To evaluate modern parametric changes. 8.To assess the quality of life of uthiravatha suronitham. 9.To document bio statistical analysis. Timepoint: 6 Months

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Countries

India

Contacts

Public ContactDr S JUSTUS ANTONY MD S

Government Siddha Medical College and Hospital, Palyamkottai

justusantony71@gmail.com9443090849

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026