Health Condition 1: M169- Osteoarthritis of hip, unspecified
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Nil: Nil
Sponsors
All India Institute of Medical Sciences (AIIMS) Rajkot, Gujarat-360110
Dr Sundip Charmode
Eligibility
Inclusion criteria
Inclusion criteria: 1. The patient provides informed consent. 2. Patients who are 64 years of age or older are also eligible [8]. 3. Any bone fractures can be treated using any modality, including closed reduction, open reduction, and internal fixation using any type of fixation device. 4. Secondary surgeries are performed to address internal fixation failures or hypertrophic nonunion.
Exclusion criteria
Exclusion criteria: 1. Patient who does not give informed consent. 2. Patients below 64 years. 3. Fractures with infection, brain injury, malignancy, systemic diseases, metabolic disorders, or those treated with hormones, steroids, vitamin D, or calcium.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. To examine the histo-morphometric features (bone cells, collagen fibers, intercellular matrix, and osteoprogenitor cells) of all four phases of fracture healing in elderly individuals. 2. To evaluate the distribution of immune cells, specifically neutrophils, macrophages, and lymphocytes, during all four phases of fracture healing. Timepoint: 1. To examine the histo-morphometric features (bone cells, collagen fibers, intercellular matrix, and osteoprogenitor cells) of all four phases of fracture healing in elderly individuals. 2. To evaluate the distribution of immune cells, specifically neutrophils, macrophages, and lymphocytes, during all four phases of fracture healing. 3. To correlate the immunological, osteogenic, and angiogenic alterations with clinical outcomes, including healing duration, complications (non-union or malunion), and patient demographics. | — |
Secondary
| Measure | Time frame |
|---|---|
| To correlate the immunological, osteogenic, and angiogenic alterations with clinical outcomes, including healing duration, complications (non-union or malunion), and patient demographics. Timepoint: 1. To examine the histo-morphometric features (bone cells, collagen fibers, intercellular matrix, and osteoprogenitor cells) of all four phases of fracture healing in elderly individuals. 2. To evaluate the distribution of immune cells, specifically neutrophils, macrophages, and lymphocytes, during all four phases of fracture healing. 3. To correlate the immunological, osteogenic, and angiogenic alterations with clinical outcomes, including healing duration, complications (non-union or malunion), and patient demographics. | — |
Countries
India
Contacts
Public ContactDr Sundip Charmode
All India Institute of Medical Sciences (AIIMS) Rajkot
Outcome results
None listed