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Oral intake of 5 mg vitamin B12 during early pregnancy improves vitamin B12 status of mothers and offsprings

Biochemical analysis of Breast Milk and children s cardio-metabolic status to understand the beneficial effect of high oral dose B12 supplement during early pregnancy on the offspring. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/02/104102
Enrollment
76
Registered
2026-02-17
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Milk cobalamin: We supplemented B12 deficient pregnant women with high oral dose (5 mg/d) of HO-B12/CN B12/placebo at early stage for 2 weeks and then continued with 2 x200 mL of milk d

Sponsors

Aarhus University Denmark
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Confirmed pregnant women with plasma B12 less than 200 pg/ml

Exclusion criteria

Exclusion criteria: Non vegetarians, cancer and the participants consuming vitamin B12 pills and the drugs known to influence vitamin B12 absorption

Design outcomes

Primary

MeasureTime frame
Beneficial effect of Vitamin B12 supplementation on breast milk and off-springsTimepoint: Early pregnancy to 4 months postpartum—

Secondary

MeasureTime frame
Normal birth weight children and healthy cardiometabolic statusTimepoint: Early pregnancy to 4 months postpartum—

Countries

India

Contacts

Public ContactDr Sadanand S Naik

Pathology Department Deenanath Mangeshkar Hospital and Research Center

sadu_naik@rediffmail.com8805375594

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026