Which drug is better for nebulization either lignocain (4%) or dexmedetomidine before intubation and after intubation

Comparison of effect of preoperative nebulized lignocaine versus nebulized dexmedetomidine for attenuation of hemodynamic responses to laryngoscopy and endotracheal intubation in the patients undergoing elective surgery under general anaesthesia - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/104091

Enrollment

Registered

2026-02-17

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: PCS-

Interventions

Intervention1: Nebulized dexmedetomidine: Patients allocated to the intervention group will receive preoperative nebulization with dexmedetomidine at a dose of 1 g/kg, diluted with normal saline to m

Eligibility

Inclusion criteria

Inclusion criteria: Adult patients aged 18 65 years of either gender, ASA physical status I or II, scheduled for elective surgery under general anaesthesia with expected duration of surgery less than 120 minutes.

Exclusion criteria

Exclusion criteria: Patients refusing consent, allergy to study drugs, haemodynamic instability, BMI more than 30 kg/m , anticipated difficult airway, laryngoscopy time more than 15 seconds or more than one intubation attempt, history of cardiac, hepatic or renal disease, upper respiratory tract infection, sore throat, or predicted difficult airway.

Design outcomes

Primary

Measure	Time frame
Mean arterial blood pressure (MAP) response during laryngoscopy and endotracheal intubation Timepoint: Before nebulization,immediately after intubation,5 minutes after intubation,post extubation	—

Secondary

Measure	Time frame
Heart rate, systolic blood pressure and diastolic blood pressure during laryngoscopy and endotracheal intubation Timepoint: Baseline, after nebulization, before intubation, 1, 5 and 10 minutes after endotracheal intubation ;Cough response at the time of extubation Timepoint: Immediately at extubation ;Incidence and severity of postoperative sore throat Timepoint: 0, 2, 4, 6, 12 and 24 hours after extubation ;Incidence of adverse events such as bradycardia, hypotension and sedation Timepoint: Intraoperative and postoperative period	—

Measure

Time frame

Heart rate, systolic blood pressure and diastolic blood pressure during laryngoscopy and endotracheal intubation Timepoint: Baseline, after nebulization, before intubation, 1, 5 and 10 minutes after endotracheal intubation ;Cough response at the time of extubation Timepoint: Immediately at extubation ;Incidence and severity of postoperative sore throat Timepoint: 0, 2, 4, 6, 12 and 24 hours after extubation ;Incidence of adverse events such as bradycardia, hypotension and sedation Timepoint: Intraoperative and postoperative period

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Countries

India

Contacts

Public ContactChanda Khatri

Dr S N Medical College

Chandakhatri90@gmail.com9414345091

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026