Impact of Continuing Versus Stopping Pain Medicine on Recovery During Breathing Tube Removal After Brain Surgery

To compare the efficacy of continuous infusion of remifentanil versus discontinuation of remifentanil during tracheal extubation in neurosurgical patients using Intraoperative Neurophysiological Monitoring- A Prospective, Randomized, Double-Blind Study - nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/104063

Enrollment

Registered

2026-02-17

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: continuous infusion of remifentanil: continuous infusion of remifentanil during tracheal extubation in neurosurgical patients using Intraoperative Neurophysiological Monitoring Control

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age 18years to 65 years 2. Elective/ emergency neurosurgery cases 3. ASA PS 1,2 and 3

Exclusion criteria

Exclusion criteria: 1. Patient refusal 2. Allergy to the drugs used in then study

Design outcomes

Primary

Measure	Time frame
To compare the efficacy of continuous infusion of remifentanil versus discontinuation of remifentanil during tracheal extubation in neurosurgical patients, using intraoperative neurophysiological monitoring (IONM), with respect to 1.hemodynamic stability 2.quality of extubation. Timepoint: at 1 min, 3 mins, 5 mins	—

Secondary

Measure	Time frame
To evaluate the effect of remifentanil infusion/discontinuation on the emergence profile (time to awakening, response to commands, extubation time). To assess the incidence of adverse events (coughing, desaturation, laryngospasm, hypertension, tachycardia, bradycardia) associated with both strategies. Timepoint: at 1 min, 3 mins, 5 mins	—

Countries

India

Contacts

Public ContactPrajna Pandit Khot

Yashoda Hospitals, Secunderabad

vishwasb216@gmail.com09914015533

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026