Health Condition 1: C00-D49- Neoplasms
Conditions
Interventions
Intervention1: Intervention Group (Dexamethasone): 8 mg oral dexamethasone once daily for 3 days, starting 4 hours before first dose of morphine.
Control Intervention1: Control Group (No prophylaxis):
Sponsors
NIL
Eligibility
Inclusion criteria
Inclusion criteria: 1.Age more than 18 years 2. Diagnosed cancer (any histology) 3. Opioid-na ve, planned for oral morphine 4. Expected to take oral morphine for at least 5 days 5. Able to understand symptom reporting and provide consent
Exclusion criteria
Exclusion criteria: 1. Current or recent corticosteroid therapy 2. Concurrent antiemetics initiated prophylactically 3. History of steroid allergy or contraindication 4. Cognitive impairment or inability to communicate 5. Uncontrolled diabetes mellitus 6. Inability to follow up for 5 day
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nausea severity score measured using a 0 10 Numerical Rating ScaleTimepoint: Day 1, Day 3, and Day 5 after initiation of oral morphine | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of vomiting episodes Rescue antiemetic use Emergency visits due to opioid-induced nausea & vomiting.Timepoint: Day 1, Day 3, Day 5 after opiod initiation | — |
Countries
India
Contacts
Public ContactSeema Mishra
AIIMS, New Delhi
Outcome results
None listed