A Study Comparing Nebulised Magnesium Sulfate and Nebulised Dexmedetomidine with Normal Saline in Reducing Blood Pressure and Heart Rate Changes During Intubation

Comparision of Effectiveness of Nebulised Magnesium Sulfate 30 mg per kg versus Nebulised Dexmedetomidine 1 Microgram per kg and Control group NS 0.9 Percent 5 mL in Attenuating the Hemodynamic Response to Laryngoscopy - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/103978

Enrollment

186

Registered

2026-02-16

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Z518- Encounter for other specified aftercare

Interventions

Intervention1: Nebulised Magnesium Sulfate: Nebulised magnesium sulfate 30 milligram per kilogram diluted to 5 milliliter administered over approximately 15 minutes and completed 15 to 20 minutes befo

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged 18 to 60 years of either gender, belonging to ASA physical status I and II, scheduled for elective surgery under general anesthesia requiring laryngoscopy and endotracheal intubation.

Exclusion criteria

Exclusion criteria: Patient refusal, Age less than 18 years and more than 60 years, anticipated difficult airway, BMI greater than 30 kg per meter square, bradycardia, heart block, uncontrolled hypertension, significant cardiovascular disease, renal or hepatic dysfunction, pregnancy, known allergy to study drugs, and patients on beta blockers or other drugs affecting hemodynamic response.

Design outcomes

Primary

Measure	Time frame
Change in Heart rate and Mean arterial pressure from baseline following laryngoscopy and endotracheal intubationTimepoint: Baseline (pre nebulization), after nebulization, immediately after laryngoscopy, and at 1, 3, 5 and 10 minutes post-laryngoscopy.	—

Secondary

Measure	Time frame
Systolic and diastolic blood pressure response to laryngoscopy and intubationTimepoint: Baseline, after nebulization, immediately after laryngoscopy, and at 1, 3, 5 and 10 minutes post intubation.;Incidence of adverse effects such as bradycardia, hypotension, hypertension, arrhythmias, nausea, vomiting, or bronchospasmTimepoint: INTRAOPERATIVE PERIOD;Requirement of rescue medications to control hemodynamic responsesTimepoint: During induction laryngoscopy & first 10 minutes after intubation	—

Measure

Time frame

Systolic and diastolic blood pressure response to laryngoscopy and intubationTimepoint: Baseline, after nebulization, immediately after laryngoscopy, and at 1, 3, 5 and 10 minutes post intubation.;Incidence of adverse effects such as bradycardia, hypotension, hypertension, arrhythmias, nausea, vomiting, or bronchospasmTimepoint: INTRAOPERATIVE PERIOD;Requirement of rescue medications to control hemodynamic responsesTimepoint: During induction laryngoscopy & first 10 minutes after intubation

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Countries

India

Contacts

Public ContactDr Harshit Jain

RUKMANI BIRLA HOSPITAL

mailtodrharshit@gmail.com9284116155

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026