Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: WITHOUT LOADING DOSE: Milrinone was Started as infusion 0.5 ug/kg/min without loading dose after patient went on cardio pulmonary bypass and continue as infusion 0.5-0.75 ug/kg/min in p
Sponsors
UNMICRC
Eligibility
Inclusion criteria
Inclusion criteria: Pediatric patients (age: 6 months to 5 years) undergoing TOF repair.
Exclusion criteria
Exclusion criteria: Patients with significant renal or hepatic dysfunction, Patients with preoperative low cardiac output syndrom ,Patients who require extracorporeal membrane oxygenation (ECMO) support
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemodynamic parameters (Heart rate, Systolic /Diastolic and Mean arterial blood pressure, Central venous pressure, Saturation,Urine Output , serum lactate level) Inotropic support requirements ( max vasoactive-inotropic score) Postoperative complications (low output syndrome, arrhythmias)Timepoint: Baseline before starting study 15 min after weaning from CPB At the end of surgery 6 hr after ICU admission 12 hr after ICU admission 24 hr after ICU admission | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of stay in ICU Evaluate the safety profile of both milrinone infusion regimens including adverse effects such as hypotension, & thrombocytopenia Volume Administration: Compare the volume administration between two group Timepoint: Baseline before starting study 15 min after weaning from CPB At the end of surgery 6 hr after ICU admission 12 hr after ICU admission 24 hr after ICU admission | — |
Countries
India
Contacts
Public ContactDrMilan Patel
U. N. Mehta Institute of Cardiology and Research Center
Outcome results
None listed