Health Condition 1: F321- Major depressive disorder, singleepisode, moderate Health Condition 2: F320- Major depressive disorder, singleepisode, mild Health Condition 3: F324- Major depressive disorder, singleepisode, in partial remission Health Condition 4: F328- Other depressive episodes Health Condition 5: F322- Major depressive disorder, singleepisode, severe without psychotic features Health Condition 6: F329- Major depressive disorder, singleepisode, unspecified Health Condition 7: F330- M
Conditions
Interventions
Intervention1: Arm 1: Unilateral Right Nostril Breathing: Subjects will be asked to adopt chin mudra in left hand (by touching the tip of index finger and thumb, and other fingers straight) kept on th
Sponsors
Center for mind body intervention through yoga CMBIY
Eligibility
Inclusion criteria
Inclusion criteria: 1. Subjects with DSM V- clinical diagnosis of Major depressive disorder. 2. Severity of depression- mild to severe. 3. Age from 18 60 years 4. Both sexes 5. Patients who consent for TMS and yoga
Exclusion criteria
Exclusion criteria: 1. Subjects with brain implants, cardiac pacemakers, cochlear implants and medication infusion devices 2. Co-morbid substance abuse (excluding nicotine dependence), psychosis, suicidal and self-injurious behaviour, mental retardation, any other DSM V anxiety disorders, OCD and related disorders. 3. Severe depression with catatonic symptoms, suicidal risk or severe psychomotor retardation. 4. Bipolar depression. 5. Currently pregnant or lactating. 6. Subjects with severe physical ailments like general medical conditions like coronary artery disease, fracture, seizure disorders, autoimmune disorders, chronic fever and those on treatment with immune-modulating agents. 7. History of ECT in past 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To study the effects of 10 minutes of Unilateral Right Nostril Breathing and Unilateral Left Nostril Breathing on Cortical Silent Period (CSP) using TMS-EMG in patients with Major Depressive DisordersTimepoint: Baseline, 5 minutes after intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| To study the effect of 10 minutes of Unilateral Right Nostril Breathing (URNB) on Short Interval Intra Cortical Inhibition (SICI), Long Interval Intra Cortical Inhibition (LICI) & Intra Cortical Facilitation (ICF) using TMS-EMG in patients with major depressive disorders Timepoint: Baseline, 5 minutes after intervention;To study the effects of 10 minutes of Unilateral Left Nostril Breathing (ULNB) on Short Interval Intra Cortical Inhibition (SICI), Long Interval Intra Cortical Inhibition (LICI) & Intra Cortical Facilitation (ICF) using TMS-EMG in patients with major depressive disorders Timepoint: Baseline, 5 minutes after intervention;To study the effects of 10 minutes of Unilateral Right nostril breathing (URNB) on patients with mild depressive disorder using Positive & Negative Affect Schedule (PANAS) in comparison with 10 minutes of breath awarenessTimepoint: Baseline, 5 minutes after intervention;To study the effects of 10 minutes of Unilateral Left nostril breathing (ULNB) on patients with mild depressive disorder using Positive & Negative Affect Schedule (PANAS) in comparison with 10 minutes of breath awarenessTimepoint: Baseline, 5 minutes after intervention | — |
Countries
India
Contacts
Public ContactDr Shravanthi KS
National Institute of Mental Health and Neurosciences
Outcome results
None listed