Comparing two ways to give medicine in frail patients for better recovery after surgery: Dose based on total body weight or on muscle mass?

Comparison of lean body mass and total body weight dosing of atracurium on residual neuromuscular blockade in frail patients: A randomized controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/103941

Enrollment

190

Registered

2026-02-16

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Z682- Body mass index (BMI) 20-29, adult

Interventions

Intervention1: Atracurium: This group will receive atracurium based on lean body mass intravenously at intubation and every 30 minutes during surgery Control Intervention1: Atracurium: This group will

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age more than 18 years of either sex 2. ASA physical status I or II or III 3. Open abdominal surgeries requiring muscle relaxant 4. Surgical duration more than 1 hour 5. Patients with frailty score of more than or equal to 1 as defined by modified 5 item frailty index (5 mFI)

Exclusion criteria

Exclusion criteria: 1. History of any neuromuscular disease 2. History of psychiatric disease, dementia, anxiety disorder 3. Need for postoperative ICU admission 4. Patient with delirium (DRS R 98 more than 18) on preoperative assessment 5. Surgeries requiring rapid sequence intubation 6. Obese patients

Design outcomes

Primary

Measure	Time frame
Residual Neuromuscular Block, TOF ratioTimepoint: Within 5 minutes postoperatively in the recovery room	—

Secondary

Measure	Time frame
Time to spontaneous recovery, TOF ratioTimepoint: Till TOF more than 0.9;Handgrip strengthTimepoint: Postoperatively;Diaphragm excursion ultrasoundTimepoint: Postoperatively;Postoperative adverse events (desaturation SpO2 less than 92%)Timepoint: In the Recovery Room;Postoperative Delirium, DRS R 98Timepoint: 24 hours post surgery	—

Countries

India

Contacts

Public ContactSamina Haider

AIIMS NEW DELHI

k.punit@yahoo.com9873106516

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026