Health Condition 1: G402- Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
Conditions
Interventions
Intervention1: Steroid therapy: Injection methyl prednisolone pulse therapy at the dose of 30milligrams per kilogram of body weight, intravenously for 5 days. Followed by prednisolone at 2milligrams p
Sponsors
All India Institute of Medical Sciences New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: Children aged between 4 to 12 years, diagnosed with focal drug refractory epilepsy with 1. At least 4 seizures a month in last 3 months. 2. A single seizure semiology with focal onset 3. Clinical semiology consistent with EEG, MRI and/or interictal PET brain scan
Exclusion criteria
Exclusion criteria: 1. DRFE that is consistent with LGS (Lennox Gastaut Syndrome) 2. More than 1 irritative focus in EEG 3. Lack of consensus on seizure onset being focal or generalized 4. Progressive neurological disorder, including neurometabolic disorders, neurodegenerative disorders, mitochondrial disorders and inborn errors of metabolism
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Comparison of EEG responsiveness in children with drug refractory focal epilepsy with secondary bilateral synchrony post treatment with steroids in terms of reduction in the mean SBS and Spike-wave index. 2. Study of the cognitive and behavioral responsiveness post treatment with steroidsTimepoint: 3 months post intervention | — |
Countries
India
Contacts
Public ContactDr Prashant Jauhari
AIIMS, New Delhi
Outcome results
None listed