Comparison of epidural bolus and infusion techniques on pain and inflammatory response in gastrointestinal cancer surgery patients

Effect of epidural morphine-ropivacaine combination bolus versus continuous infusion on pain and IL-6, IL-10 levels in patients undergoing gastrointestinal oncosurgeries - a prospective randomized clinical trial - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/103899

Enrollment

Registered

2026-02-16

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C15-C26- Malignant neoplasms of digestive organs

Interventions

Intervention1: Epidural morphine-ropivacaine intermittent bolus: Bolus with morphine 0.05 mg/kg (not more than 3 mg) along with 10 ml of ropivacaine 0.2% approximately 15 min before surgical incision.

Eligibility

Inclusion criteria

Inclusion criteria: 1)ASA I-III undergoing GastroIntestinal Cancer Surgeries 2) scheduled for elective open GI oncosurgeries

Exclusion criteria

Exclusion criteria: 1.Known allergy to Local Anaesthetic Agents and opioids 2.Patients on chronic opioid therapy 3.Patients with spine deformities, post spinal surgeries 4.Patients undergoing thoracic surgeries or VATS 5.Coagulopathy 6. Infection at the injection site 7. Pregnancy 8. Patient refusal

Design outcomes

Primary

Measure	Time frame
To compare the efficacy of pain relief between epidural bolus and continuous infusion of epidural morphine-ropivacaine combination using the Numeric Rating Scale (NRS) for pain and to correlate pain scores with serum interleukin levels (IL-6 and IL-10) in patients undergoing major gastrointestinal oncosurgeriesTimepoint: To compare the efficacy of pain relief between epidural bolus and continuous infusion of epidural morphine-ropivacaine combination using the Numeric Rating Scale (NRS) for pain and to correlate pain scores with serum interleukin levels (IL-6 and IL-10) in patients undergoing major gastrointestinal oncosurgeries for 48 hrs post op	—

Measure

Time frame

To compare the efficacy of pain relief between epidural bolus and continuous infusion of epidural morphine-ropivacaine combination using the Numeric Rating Scale (NRS) for pain and to correlate pain scores with serum interleukin levels (IL-6 and IL-10) in patients undergoing major gastrointestinal oncosurgeriesTimepoint: To compare the efficacy of pain relief between epidural bolus and continuous infusion of epidural morphine-ropivacaine combination using the Numeric Rating Scale (NRS) for pain and to correlate pain scores with serum interleukin levels (IL-6 and IL-10) in patients undergoing major gastrointestinal oncosurgeries for 48 hrs post op

—

Secondary

Measure	Time frame
Comparison of postoperative rescue analgesia consumption Timepoint: Comparison of postoperative rescue analgesia consumption till 48hrs in postop period;Comparison of Intraoperative hemodynamics in these 2 groupsTimepoint: Till the end of surgery bt12-24 hrs duration;Comparison of Time to early mobilisation from bedTimepoint: within 1-2 week duration postop;Comparison of Length of Hospital stayTimepoint: 1 week -3 week;Comparison of quality of life at 3 monthsTimepoint: 3 months	—

Measure

Time frame

Comparison of postoperative rescue analgesia consumption Timepoint: Comparison of postoperative rescue analgesia consumption till 48hrs in postop period;Comparison of Intraoperative hemodynamics in these 2 groupsTimepoint: Till the end of surgery bt12-24 hrs duration;Comparison of Time to early mobilisation from bedTimepoint: within 1-2 week duration postop;Comparison of Length of Hospital stayTimepoint: 1 week -3 week;Comparison of quality of life at 3 monthsTimepoint: 3 months

—

Countries

India

Contacts

Public ContactAjit Kumar

AIIMS Rishikesh

ajitdr.ajit@gmail.com9910789377

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026