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Does a pill called midodrine taken before surgery help to prevent blood pressure drops after IV anaesthesia starts

Efficacy of preoperative oral midodrine as a prophylaxis against post induction hypotension in patients undergoing elective surgery under general anaesthesia - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/02/103884
Enrollment
414
Registered
2026-02-16
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Preoperative oral midodrine: The study aims to evaluate the incidence of post induction hypotension with general anaesthesia after preoperative oral midodrine. Patients with hypertensio

Sponsors

All India Institute of Medical Sciences, Jodhpur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All ASA 1 patients who needs Surgical intervention under General Anaesthesia included in this study

Exclusion criteria

Exclusion criteria: Hypertensive patient, DM, Known cardiac patients, CKD, Liver disease patients, Urinary retention, Pheochromocytoma, Thyrotoxicosis, Patients whose are taking Digitalis and beta blockers, glaucoma

Design outcomes

Primary

MeasureTime frame
To find out the incidence of post induction hypotension with General anaesthesia after preoperative medication with oral midodrine 5mgTimepoint: Patients vitals will be monitored from the time of induction to 20 minutes of induction .. study will be continued over period of 1 year after the date of enrolment

Secondary

MeasureTime frame
To find: Intraoperative phenylephrine consumption. Measurement of serial change in MAP & HR after induction. Incidence of Frequency of complications like reactive hypertension & bradycardia. Timepoint: Patient vitals will be monitored from the time of induction to 20 minutes of induction, study will be continued over a period of 1 year after the date of approval

Countries

India

Contacts

Public ContactDr Pradeep Kumar bhatia

All India Institute of Medical Sciences, Jodhpur

pk_bhatia@yahoo.com9829159665

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026