Comparing a combination of turmeric and zinc against a steroid to treat fibrosis and burning sensation of oral cavity

Comparative study to evaluate the efficacy of turmizinc and point one percent triamcinolone acetonide oral paste in the treatment of oral submucous fibrosis A Randomized controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/103850

Enrollment

Registered

2026-02-13

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K135- Oral submucous fibrosis

Interventions

Intervention1: Turmizinc oral paste: oral paste containing curcumin along with lycopene and zinc for 2 months Control Intervention1: 0.1 percent triamcinolone acetonide oral paste: 0.1 percent triamci

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients diagnosed with OSMF clinically and histopathologically. 2. Patients with age group: 18 yr - 60 yr 3. Patients with OSMF Stage I and Stage II (More et al. classification 2011) 4. Patients who have not been treated previously for OSMF.

Exclusion criteria

Exclusion criteria: 1. Patients with other mucosal lesions other than OSMF 2. Patients with trismus due to other reasons. 3. Patients who have already been given or are currently on any treatment for OSMF 4. Patients with systemic ailments having OSMF.

Design outcomes

Primary

Measure	Time frame
Increase in mouth opening (interincisal distance) Reduction in burning sensation (VAS score) Increase in tongue protrusion which will be assessed at 7 day, 15 days, 30 days and 60 days from the start of treatment Timepoint: Increase in mouth opening (interincisal distance) Reduction in burning sensation (VAS score) Increase in tongue protrusion	—

Secondary

Measure	Time frame
NilTimepoint: Nil	—

Countries

India

Contacts

Public ContactDr Vagisha Choudhary

D Y Patil University School Of Dentistry

mandavi.waghmare@dypatil.edu8940729691

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026