Health Condition 1: I208- Other forms of angina pectoris
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Nil: Nil
Control Intervention1: Biomarker assay: Blood samples to be taken for biomarker assay before surgery and followup to identify sepsis and to study the bi
Sponsors
Amrita Institute of Medical Science Kochi
Randox Laboratories India Pvt Limited
Eligibility
Inclusion criteria
Inclusion criteria: All adult patients over the age of 18 years undergoing off-pump cardiac surgery.
Exclusion criteria
Exclusion criteria: Patients with preoperative colonization or preoperative sepsis, patients on preoperative antibiotics, patients undergoing on-pump cardiac surgery and those who are known cases of autoimmune diseases and blood cell diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the predictability of culture positive and culture negative sepsis in off-pump adult cardiac surgery patient using the Randox Hyperinflammation Biochip [9 biomarkers; Interleukin-1 Beta (IL-1 Beta), Interleukin-2 (IL-2), Interleukin-6 (IL-6),Interferon Gamma (IFN-Gamma), Tumor Necrosis Factor- Alpha (TNF-Alpha), Monocyte Chemoattractant Protein-1 (MCP-1), Interleukin-15 (IL-15), Ferritin and D-Dimer] with the clinical risk scores, the Euroscore II.Timepoint: the end point is development of sepsis as per SOFA score rise of more than 2 within the primary postoperative intensive care admission which may last from 2 to 5 days | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the prediction of sepsis by the above-mentioned biomarkers and correlate it to the standard Euro-score II risk prediction of sepsis in cardiac surgery patients.Timepoint: During ICU stay and upto 48 hours postoperatively | — |
Countries
India
Contacts
Public ContactDr. Thushara Madathil
Amrita Institute of Medical Sciences
Outcome results
None listed