Health Condition 1: G55- Nerve root and plexus compressionsin diseases classified elsewhere
Conditions
Interventions
Intervention1: Dexmedetomidine plus ketamine vs Dexmedetomidine: (Dexmedetomidine ) alone-1 ug/kg iv over 10 minutes before induction
(Ketamine+ dexmedetomidine ) combinatin- 0.5 mg/kg+0.5ug/kg iv
Sponsors
Heritage Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: patients posted for dorsolumbar spine surgery
Exclusion criteria
Exclusion criteria: Patient with known allergy to study drugs Pregnancy and lactating women. Neurological disorder affecting pain perception. Minimal invasive/Endoscopic spinal surgerys. Patient with known Hypertension.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intra-operative hemodynamic stability, assessed by: Heart rate (HR) Systolic blood pressure (SBP) Diastolic blood pressure (DBP) Mean arterial pressure (MAP) Timepoint: Baseline before induction of anesthesia After Induction Post-Intubation after Positioning (Prone) Every 15 min Intraoperatively End of surgery Post -Extubation | — |
Secondary
| Measure | Time frame |
|---|---|
| Post-operative pain intensity, assessed using: Visual Analog Scale (VAS) / Numerical Rating Scale (NRS) at fixed time intervals Total post-operative analgesic/opioid requirement within the first 24 hours Time to first rescue analgesia Incidence of adverse effects, including: Bradycardia Hypotension Nausea & vomitingTimepoint: Postoperative pain will be assessed using Visual Analogue Scale (VAS) at 0, 4, 8, 12, 16, 20 & 24 hours postoperatively. Total rescue analgesic consumption will be recorded over the first 24 hours postoperatively. Adverse effects (bradycardia, hypotension, nausea, vomiting, sedation) will be monitored intraoperatively & for 24 hours postoperatively. | — |
Countries
India
Contacts
Public ContactDr Col Shyamal Maity
Heritage Institute of Medical Sciences
Outcome results
None listed