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COMPARING THE EFFECT OF MODIFED PAL TREATMENT AND STANDARD TREATMENT IN PATIENTS WITH INFECTION ASSOCIATED LOW BLOOD PRESSURE

COMPARISON OF EFFICACY OF MODIFIED PAL THERAPY WITH STANDARD THERAPY IN PATIENTS WITH SEPTIC SHOCK : A RANDOMISED CONTROLLED TRIAL - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/02/103813
Enrollment
80
Registered
2026-02-13
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R578- Other shock

Interventions

Intervention1: Modified PAL therapy: PAL therapy (PEEP,Albumin,Lasix) : PEEP will be titrated as per ARDS net protocol (Low PEEP/ High FiO2), Injection Albumin 20% (weight/ volume) 100 ml twice a day

Sponsors

ALL INDIA INSTITUTE OF MEDICAL SCIENCES, JODHPUR
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with septic shock as per Surviving Sepsis Guidelines 2021 with VExUS grade more than or equal to 1

Exclusion criteria

Exclusion criteria: 1. Poor window to perform VExUS 2. Patients with cirrhosis-Child Pugh B and C 3. Patients who underwent liver transplantation 4. Pregnant females 5. Patients with chronic kidney disease stage IV or V 6. Patients with renal transplantation 7. Patients with congestive heart failure.

Design outcomes

Primary

MeasureTime frame
To compare the efficacy of PAL therapy with Standard therapy on the incidence of AKI as per KDIGO guidelines in patients with septic shockTimepoint: 7 days—

Secondary

MeasureTime frame
Correlation of venous congestion (VExUS) with SOFA and APACHE IITimepoint: DAY 1 AND DAY 2;Need for renal replacement therapyTimepoint: DAY 7;Length of ICU stayTimepoint: DAY 28;Length of mechanical ventilationTimepoint: DAY 28—

Countries

India

Contacts

Public ContactBHARAT PALIWAL

ALL INDIA INSTITUTE OF MEDICAL SCIENCES , JODHPUR

docbpali@gmail.com9588089378

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026