which is better to treat pyorrhea:Surgery or repeated scaling

Comparative evaluation of MIP-1 alpha biomarker in full mouth access flap surgery vs repeated non-surgical periodontal therapy in Stage 3 Grade B Periodontitis: A Randomised Clinical Trial - nil

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/103744

Enrollment

Registered

2026-02-12

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: non surgical periodontal therapy: non surgical periodontal therapy is 1st line treatment before any stage of periodontitis Control Intervention1: Access flap surgery: access flap surger

Eligibility

Inclusion criteria

Inclusion criteria: Systemically healthy individuals with diagnosis of Stage III Grade B Generalized Periodontitis (according to the 2017 AAP/EFP classification) and no previous history of periodontal surgery

Exclusion criteria

Exclusion criteria: 1. Past or current tobacco users (both smoking and chewing tobacco). 2. Pregnant or lactating females. 3. Patients with systemic diseases (e.g., uncontrolled diabetes, autoimmune disorders). 4. Patients with acute oral infections, mucosal lesions, or salivary gland dysfunction. 5. History of orthodontic treatment or presence of full-mouth fixed prostheses.

Design outcomes

Primary

Measure	Time frame
To comparatively evaluate the change in MIP-1 alpha levels at baseline and 3 months post-full mouth access flap surgery v/s repeated non-surgical periodontal therapy in patients with Stage 3 Grade B Periodontitis Timepoint: To comparatively evaluate the change in MIP-1 alpha levels at baseline and 3 months post-full mouth access flap surgery v/s repeated non-surgical periodontal therapy in patients with Stage 3 Grade B Periodontitis	—

Measure

Time frame

To comparatively evaluate the change in MIP-1 alpha levels at baseline and 3 months post-full mouth access flap surgery v/s repeated non-surgical periodontal therapy in patients with Stage 3 Grade B Periodontitis Timepoint: To comparatively evaluate the change in MIP-1 alpha levels at baseline and 3 months post-full mouth access flap surgery v/s repeated non-surgical periodontal therapy in patients with Stage 3 Grade B Periodontitis

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Secondary

Measure	Time frame
1. To compare the changes in MIP-1-alpha levels in GCF v/s saliva of both groups. 2. To evaluate the clinical periodontal parameters (Plaque Index, Gingival Index, Probing Pocket Depth, Clinical Attachment Loss) at baseline & three months post-access flap surgery vs repeated non-surgical periodontal therapy. 3. To correlate the changes in MIP-1 alpha levels in GCF & saliva with the changes in clinical periodontal parameters after access flap surgery & non-surgical periodontal therapy. Timepoint: All the parameters ie MIP-1 alpha in saliva & gcf,clinical periodontal parameters will be assessed at baseline in both groups without any intervention followed by surgery & repeated non surgical therapy.3month post both treatment completion,all these parameters will be assessed again.	—

Measure

Time frame

1. To compare the changes in MIP-1-alpha levels in GCF v/s saliva of both groups. 2. To evaluate the clinical periodontal parameters (Plaque Index, Gingival Index, Probing Pocket Depth, Clinical Attachment Loss) at baseline & three months post-access flap surgery vs repeated non-surgical periodontal therapy. 3. To correlate the changes in MIP-1 alpha levels in GCF & saliva with the changes in clinical periodontal parameters after access flap surgery & non-surgical periodontal therapy. Timepoint: All the parameters ie MIP-1 alpha in saliva & gcf,clinical periodontal parameters will be assessed at baseline in both groups without any intervention followed by surgery & repeated non surgical therapy.3month post both treatment completion,all these parameters will be assessed again.

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Countries

India

Contacts

Public Contactanushka

Army dental centre ,research and referral

tprasanthavin@gmail.com8284851155

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026