Effect of melatonin before surgery helps to reduce anxiety and keep vitals stable

Effect of preoperative oral melatonin on perioperative anxiety and hemodynamic response to intubation: A double-blind randomized controlled trial in patients undergoing surgery under general anesthesia - Nil

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/103734

Enrollment

Registered

2026-02-12

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Tablet Melatonin 6 mg: Tablet given 60 minutes before general anaesthesia induction Control Intervention1: Tablet Multivitamin: Tablet given 60 minutes before general anaesthesia induct

Eligibility

Inclusion criteria

Inclusion criteria: Patients who are willing to give written consent ASA 1/2 patients who will undergo surgical procedures under general anaesthesia No use of anxiolytic narcotic 24 hours before surgery Non pregnant females

Exclusion criteria

Exclusion criteria: Patient with reduced level of consciousness Known history of allergy to drugs Advanced hepatic renal and respiratory diseases Patients with anticipated difficult Airway Patients with uncontrolled hypertension and diabetes mellitus

Design outcomes

Primary

Measure	Time frame
Hamilton anxiety scoreTimepoint: Pre-operative and post-operative at 2 hours and 6 hours post-op	—

Secondary

Measure	Time frame
Hemodymanics, VAS score, Ramsay sedation score, side effectsTimepoint: Preoperative, intra-operative & post-operatively at 2 hours & 6 hours	—

Countries

India

Contacts

Public ContactSwathi N

Bangalore medical college and research institute

drmadhukp@gmail.com9380455534

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026