Health Condition 1: K00-K95- Diseases of the digestive system
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Nil: Nil
Intervention3: Nil: Nil
Intervention4: Target controlled infusion based total intravenous anesthesia: General anesthesia will be maintained using target
Sponsors
Dr. Ram Manohar Lohia Institute of Medical Sciences, Vibhuti Khand, Gomtinagar, Lucknow, UP
Eligibility
Inclusion criteria
Inclusion criteria: Adults aged 18 to 65 years ASA physical status I and II Undergoing elective major gastroabdominal surgery under general anesthesia Provided written informed consent
Exclusion criteria
Exclusion criteria: Known allergy to propofol or remifentanil Significant cardiac, hepatic, or renal disease BMI more than 35 Surgery duration more than 8 hr Neurological or psychiatric conditions Pregnant or lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean time to extubation after discontinuation of Propofol and Remifentanil infusionTimepoint: Measured from stoppage of anesthetic infusion to removal of endotracheal tube at the end of surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Average intraoperative Bispectral Index valuesTimepoint: Recorded at predefined intervals during the intraoperative period;Intraoperative heart rate & mean arterial pressureTimepoint: Recorded at baseline & at predefined intervals during surgery;Time to return of spontaneous ventilation after discontinuation of anesthetic infusionTimepoint: Measured from stoppage of anesthetic infusion until spontaneous respiratory effort is observed at the end of surgery;Total intraoperative consumption of Propofol & Remifentanil during maintenance phaseTimepoint: Calculated at the end of surgery;Incidence of postoperative nausea & vomitingTimepoint: Within the first 24 hours after surgery | — |
Countries
India
Contacts
Public ContactDr Prashasti
Dr RML IMS, Lucknow
Outcome results
None listed