A Study Comparing three different treatments for painful mouth condition (oral lichen planus)

Assessment Of Efficacy Of Topical Oromucosal Paste Containing 10% Nigella Sativa Vs 10% Curcumin Vs 0.1 % Triamcinolone Acetonide In Management Of Symptomatic Oral Lichen Planus - A Randomised Controlled Trial - nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/103584

Enrollment

Registered

2026-02-10

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L439- Lichen planus, unspecified

Interventions

Intervention1: Topical oromucosal paste containing 10% Nigella Sativa: Topical oromucosal paste containing 10% Nigella Sativa applied over the lesion 3 to 4 times daily for 4 weeks Intervention2:

Eligibility

Inclusion criteria

Inclusion criteria: Clinically and histopathologically proven cases of symptomatic Oral lichen planus. Individuals within the age group of 20-60 years. Both genders. Willingness to participate in the study.

Exclusion criteria

Exclusion criteria: Histopathologically proven OLP with dysplastic changes. Not willing to participate in study Previously treated cases of Oral lichen planus Lactating or pregnant women Allergic patients, immunocompromised patients, systemic illness Asymptomatic patients

Design outcomes

Primary

Measure	Time frame
If 10% topical Nigella Sativa oromucosal paste and 10% topical Curcumin oromucosal paste therapy is found to be effective and superior in patients with symptomatic oral lichen planus, it can be used as a therapeutic agent either as a monotherapy or as an adjunct to conventional therapy in management lichen planus.Timepoint: At baseline and every week upto 1 month	—

Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public ContactDr G V Murali Gopika Manoharan

Tamil Nadu Government Dental College And Hospital

gvmgm@hotmail.com9444381872

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026