Effect of Warmed and Activated Root Canal Cleaning Solution on Pain in Painful Teeth: A Clinical Trial

Temperature-Modulated and Activated Sodium Hypochlorite Irrigation in Symptomatic Irreversible Pulpitis: A Randomized Control Trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/103472

Enrollment

180

Registered

2026-02-09

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: Cold Sodium Hypochlorite: During biomechanical preparation, irrigation will be carried out using Cold Sodium Hypochlorite (0 2 C), with and without passive ultrasonic activation. Inter

Eligibility

Inclusion criteria

Inclusion criteria: Healthy subjects between 18 and 50 years of age. Symptomatic irreversible pulpitis Mandibular 1st and 2nd molars. The preoperative pain score corresponding to 54 mm on the Heft Parker Visual Analogue Pain Scale (HP-VAS) No analgesics for at least 6 hours before the visit.

Exclusion criteria

Exclusion criteria: Periapical pathology Teeth with periodontal pocket, calcified canals, aberrant root canal morphology, root resorption. Prior endodontic intervention for the same tooth. Pregnant or lactating patients and systemic diseases/medications.

Design outcomes

Primary

Measure	Time frame
The effectiveness of sodium hypochlorite will be evaluated based on the patient s pain response following BMP and irrigation, recorded using the Visual Analogue Scale (VAS).Timepoint: 6 hours, 24 hours, 48 hours and 72 hours	—

Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public ContactDr Shweta Verma

Himachal Dental College and Hospital

goelmuni2012@gmail.com9816034034

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026