Comparing Low vs. High Doses of a Safe Sedative Added to Numbness Medicine for Knee Surgery Pain Relief After Total Knee Replacement

Comparison of two different doses of dexmedetomidine as an adjuvant to levo-bupivacaine in ultrasound guided adductor canal block for postoperative analgesia in total knee replacement-A Prospective randomized double blinded Study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/103465

Enrollment

Registered

2026-02-09

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M236- Other spontaneous disruption of ligament(s) of knee

Interventions

Intervention1: ultrasound guided adductor canal block with levobupivacaine and dexmedetomidine: Ultrasound guided adductor canal block performed at the end of surgery using 15ml of 0.25 % levobupivaca

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing elective TKR Patient s belonging to American society of Anaesthesiologist class 1 and 2

Exclusion criteria

Exclusion criteria: Patient who does not give consent for the study Patient with any active infection at the site of administration of block Emergency surgeries Patients with local anesthetic allergy Presence of any pre-existing neuropathies Anticoagulation or bleeding disorders Patient with beta blockers Patient with cardiac diseases

Design outcomes

Primary

Measure	Time frame
To compare the duration of analgesia provided by the two different doses of dexmedetomidineTimepoint: 24 hours after surgery	—

Secondary

Measure	Time frame
1.To record and compare the total amount and timing of rescue analgesia administered within 24hours. 2.To evaluate any side effects 3.Comparision of VAS score 4.To see Ramsay sedation scoreTimepoint: 24 hours after surgery	—

Countries

India

Contacts

Public ContactDr Monu Yadav

Nizams institute of medical sciences

monubalbir@yahoo.co.in9490213460

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026