Comparing Dexmedetomidine and Clonidine with an Ultrasound-Guided TAP Block for Better Pain Relief After Cesarean Section

A comparative study of efficacy of Dexmedetomedine versus Clonidine as an adjuvant to Ropivacaine(0.2%) in ultrasound guided Transverse Abdominis Plane Block for patients undergoing lower segment cesarean section - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/103445

Enrollment

Registered

2026-02-09

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O00-O9A- Pregnancy, childbirth and the puerperium

Interventions

Intervention1: Dexmedetomedine: One group will receive a TAP block with intra-fascial injection via in plane approach of Ropivacaine (0.2%) and Dexmedetomidine 1 mcg/kg as an additive after lower seg

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA grade I or II fit patients. 2. Patients of child bearing age 3. Patients undergoing lower segment cesarean sections under spinal anaesthesia. 4. Haemodynamically stable patients with all routine investigations within normal limits without any other co-morbidities. 5. Patients who are not on any cardiac related drugs. 6. Availability of written informed consent from concerned patient.

Exclusion criteria

Exclusion criteria: 1. Patients not willing to participate in this study. 2. Patients with ASA physical status III and above physical status. 3. Patients with uncontrolled systemic disorders like neurological, cardiac, metabolic, renal, pulmonary disorders, hepatic disease with coagulation abnormalities etc. 4. Patients having local infection at the site where needle for block was to be inserted 5. Patients with bleeding or coagulation disorders. 6. Patients with known allergies to the study drugs.

Design outcomes

Primary

Measure	Time frame
To compare the efficacy of dexmedetomidine versus clonidine as an adjuvant to ropivacaine (0.2%) in ultrasound-guided transverse abdominis plane block in patients undergoing lower segment cesarean section on post operative analgesia.Timepoint: The Visual Analogue Scale Score will be recorded 20 minutes after shifting to postoperative recovery room, 1,3,6,12 and 24 hours by an investigator blinded to the group assignment	—

Measure

Time frame

To compare the efficacy of dexmedetomidine versus clonidine as an adjuvant to ropivacaine (0.2%) in ultrasound-guided transverse abdominis plane block in patients undergoing lower segment cesarean section on post operative analgesia.Timepoint: The Visual Analogue Scale Score will be recorded 20 minutes after shifting to postoperative recovery room, 1,3,6,12 and 24 hours by an investigator blinded to the group assignment

—

Secondary

Measure	Time frame
To find out any complications & hemodynamic parameter monitoring of the patient (Pulse rate, Blood Pressure Monitoring)Timepoint: 0, 2, 4, 6, 12 & 24 hours;Sedation scoreTimepoint: The sedation caused by alpha 2 agonist additives will be measured by Ramsay sedation scores at 0,2 ,4, 6, 12, 24 hours	—

Countries

India

Contacts

Public ContactDr Shilpa Sarang Kore

Dr D Y Patil Medical College and Hospital, Pimpri, Pune

shilpasale@gmail.com9767002436

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026