Health Condition 1: K049- Other and unspecified diseases ofpulp and periapical tissues
Conditions
Interventions
Intervention1: Biological sample collection with molecular immunological analysis - GROUP 1(ECC): Collection of peripheral venous blood followed by PCR based analysis of innate and adaptive immune mar
Sponsors
Niveditha R
Eligibility
Inclusion criteria
Inclusion criteria: Children diagnosed with Early Childhood caries, or ECC with dental abscesses based on clinical and radiographic examination Caries free, age matched healthy children serving as controls Children whose parents/guardians provide informed written consent Children who are systemically healthy at the time of enrollment
Exclusion criteria
Exclusion criteria: Children with systemic diseases,immunological disorders , or hematological abnormalities. Children on antibiotic , anti-inflammatory, or immunosuppressive therapy within the preceding 4 weeks Children with acute systemic infections at the time of sample collection Children with a history of bleeding disorders or on medication affecting coagulation Childrens whose parents/guardians do not consent to participation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of immunological and hematological profiles, including PCR-based expression of innate and adaptive immune markers, among children with early childhood caries, early childhood caries with abscess, and caries-free healthy controls at baselineTimepoint: At baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparsion of demographic and clinical parameters among the study groups. Assessment of associated clinical signs and symptoms in children with early childhood caries and early childhood caries with abscess. Immunohistochemical expression patterns of selected immune markers at baseline.Timepoint: At baseline | — |
Countries
India
Contacts
Public ContactDr Ramesh R
Saveetha Dental College and Hospitals
Outcome results
None listed