ROLE OF MECHANICAL BOWEL PREPARATION WITH ORAL ANTIBIOTICS IN COLORECTAL SURGERIES

Combined Oral Antibiotics with Mechanical Bowel Preparation Outcomes in Colorectal Surgery- A RANDOMIZED CONTROL TRIAL - COMBO-CRS Trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/103337

Enrollment

130

Registered

2026-02-09

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K918- Other intraoperative and postprocedural complications and disorders of digestive system

Interventions

Intervention1: Mechanical bowel preparation with Oral Antibiotics: 2L POLYETHYLENE GLYCOL to be taken at 1800 h Oral METRONIDAZOLE 2G at 1900 h and oral RIFAXIMIN 550 MG at 2200 h Control Interventio

Eligibility

Inclusion criteria

Inclusion criteria: All Patients requiring colorectal surgery

Exclusion criteria

Exclusion criteria: Patient not willing for the study Emergency surgeries Patients who did not follow the designated protocol due to medical contraindications

Design outcomes

Primary

Measure	Time frame
Incidence of SSIsTimepoint: any time up to 30 days postoperative period and up to discharge	—

Secondary

Measure	Time frame
Length of hospital stay Timepoint: upto discharge from hospital;Time to return to normal activitiesTimepoint: upto discharge from hospital & 30 days postoperative period;Anastomotic leakageTimepoint: upto discharge from the hospital & 30 days postoperative period;Postop ileusTimepoint: upto discharge from the hospital & 30 days postoperative period;MortalityTimepoint: upto discharge from the hospital & 30 days postoperative period;Readmission ratesTimepoint: upto discharge from the hospital & 30 days postoperative period	—

Measure

Time frame

Length of hospital stay Timepoint: upto discharge from hospital;Time to return to normal activitiesTimepoint: upto discharge from hospital & 30 days postoperative period;Anastomotic leakageTimepoint: upto discharge from the hospital & 30 days postoperative period;Postop ileusTimepoint: upto discharge from the hospital & 30 days postoperative period;MortalityTimepoint: upto discharge from the hospital & 30 days postoperative period;Readmission ratesTimepoint: upto discharge from the hospital & 30 days postoperative period

—

Countries

India

Contacts

Public ContactDr Mohammed Fahim Ali A

Indira Gandhi Medical College

Puneetdr1@gmail.com9418151939

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026