Health Condition 1: J960- Acute respiratory failure
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Nil: Nil
Intervention3: Nil: Nil
Intervention4: Nil: Nil
Intervention5: Nil: Nil
Sponsors
Dr Robin Manidas
Eligibility
Inclusion criteria
Inclusion criteria: Patients who are admitted to intensive care units and require Invasive mechanical ventilation for greater than 72 hours
Exclusion criteria
Exclusion criteria: 1.Patient ventilated for less than 72 hours. 2.Consent refusal by patient or next of kin. 3.Pre-existing neuromuscular disorders affecting respiratory muscles. 4.Known diaphragmatic paralysis or prior diaphragmatic surgery/trauma 5.Patients in whom acquisition of reliable diaphragmatic ultrasound images is difficult. 6.Pneumothorax or active large pleural effusion or pregnancy preventing diaphragm assessment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of this study is the rate of change in diaphragmatic function over the first five days of mechanical ventilation, assessed by diaphragmatic thickening fraction (TFdi), diaphragmatic excursion and tissue dopplerTimepoint: 1. At baseline ( time of initiation of mechanical ventilation) 2. At day 5 of mechanical ventilation | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Secondary outcomes include the impact of ventilatory mode (volume-controlled versus pressure-controlled) on diaphragmatic function. Timepoint: 1. At baseline ( time of initiation of mechanical ventilation) 2. At day 5 of mechanical ventilation;2. The study will also co-relate the diaphragmatic function with changes in peripheral muscle thickness (rectus abdominis, rectus femoris) over Day 5Timepoint: 1. At baseline ( time of initiation of mechanical ventilation) 2. At day 5 of mechanical ventilation | — |
Countries
India
Contacts
Public ContactDr Sagar M S
Kasturba Medical College, Manipal
Outcome results
None listed