Comparison of different oxygen delivery methods during a lung biopsy procedure using endoscopy

Comparative study of conventional oxygen therapy and graded high flow nasal cannula oxygenation during conscious sedation EBUS-TBNA: A Randomized Controlled Trial (OXY-EBUS Trial)

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/103308

Enrollment

380

Registered

2026-02-09

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J988- Other specified respiratory disorders

Interventions

Intervention1: High flow nasal oxygen: Divided into 4 arms- Arm 1 - 40%, 30L Arm 2 - 100%, 30L Arm 3 - 40%, 50L Arm 4 - 100%, 50L Control Intervention1: Conventional oxygen therapy: By using nasal pro

Eligibility

Inclusion criteria

Inclusion criteria: 1.Adults more than 18 years scheduled for diagnostic EBUS-TBNA under conscious sedation. 2.Able to consent/willing to participate.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Desaturation eventsTimepoint: Baseline	—

Secondary

Measure	Time frame
Number of desaturation eventsTimepoint: During procedure;Pre and post procedure pCo2 levels (blood gas analysisTimepoint: Pre and post procedure;Patient comfort assessed on visual analogue scale (0-extreme discomfort, 100-very comfortable) Bronchoscopist satisfaction assessed on visual analogue scale (0-unsatisfied, 100-very satisfied)Timepoint: Post procedure;Post procedure nasal dryness or discomfort (0-severe dryness, 100-no dryness)Timepoint: Post procedure	—

Measure

Time frame

Number of desaturation eventsTimepoint: During procedure;Pre and post procedure pCo2 levels (blood gas analysisTimepoint: Pre and post procedure;Patient comfort assessed on visual analogue scale (0-extreme discomfort, 100-very comfortable) Bronchoscopist satisfaction assessed on visual analogue scale (0-unsatisfied, 100-very satisfied)Timepoint: Post procedure;Post procedure nasal dryness or discomfort (0-severe dryness, 100-no dryness)Timepoint: Post procedure

—

Countries

India

Contacts

Public ContactVENKAT RAJ G

AIIMS

gvenkatraj1996@gmail.com8973448299

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026