Use of blood products to accelerate tooth movement during braces treatment in adults

Effects of Autologous Leukocyte-Platelet Rich Fibrin (L-PRF) on the Rate of Maxillary Canine Retraction During Comprehensive Orthodontic Treatment A Randomized Split Mouth Clinical Trial - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/103088

Enrollment

Registered

2026-02-05

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 8- Other Procedures

Interventions

Intervention1: L-PRF and T-Spring: L-PRF plug will be placed into maxillary first premolar extraction socket and canine retraction will be carried out by using T spring Control Intervention1: T Spring

Eligibility

Inclusion criteria

Inclusion criteria: Class I bimaxillary dentoalveolar proclination or Class II div 1 malocclusion and minimum crowding and spacing, requiring either all 1st premolars or only upper 1st premolars extraction for comprehensive orthodontic treatment. Presence of full complement of teeth except 3rd molars Good oral hygiene

Exclusion criteria

Exclusion criteria: History of complete or incomplete comprehensive orthodontic treatment, Subject who fails to maintain good oral hygiene all through the orthodontic treatment, Subjects with pregnancy, Subjects having any known syndrome or metabolic disorder affecting calcium and phosphate metabolism, Subjects on long-term medication like NSAID S or steroids, Lack of manual dexterity, Any medications for systemic illness, History of recent bacterial or viral infection, Known blood disorders like thrombocytopenia, leukopenia etc., Any dentofacial deformities like cleft lip and palate.

Design outcomes

Primary

Measure	Time frame
To estimate the effects of L-PRF on the rate of maxillary canine retraction by frictionless mechanics during comprehensive orthodontic treatment.Timepoint: 12 weeks	—

Secondary

Measure	Time frame
To evaluate the effects of L-PRF on the concentration of RANKL and OPG in GCF during comprehensive orthodontic treatment.Timepoint: 12 weeks;To correlate the rate of canine retraction by frictionless mechanics with the concentrations of biomarkers (RANKL and OPG) in GCF.Timepoint: 12 weeks	—

Countries

India

Contacts

Public ContactAshok Kumar Jena

AIIMS BHUBANESWAR

dent_ashok@aiimsbhubaneswar.edu.in9438884077

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026