Comparing Three Drugs In The Form Of Dental Injections As Intervention To Reduce Tooth Pain During Root Canal Treatment In Participants With Severe Toothache

Comparative Evaluation Of Efficacy Of Intraligamentary Injection Using Articaine, Ketorolac And Dexamethasone For Reduction Of Endodontic Pain In Symptomatic Irreversible Pulpitis: A Randomized Double Blinded Clinical Study - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/103066

Enrollment

106

Registered

2026-02-05

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: KETEROLAC: THREE TO SIX MONTHS Intervention2: DEXAMETHASONE: THREE TO SIX MONTHS Control Intervention1: ARTICAINE: THREE TO SIX MONTHS

Eligibility

Inclusion criteria

Inclusion criteria: Healthy individuals with no systemic diseases. Mandibular molars diagnosed as hot tooth with symptomatic irreversible pulpitis. Carious exposed symptomatic mandibular molars. A positive and prolonged response to cold tests and electric pulp tests.

Exclusion criteria

Exclusion criteria: Patients with a history of known or suspected drug abuse, and patients taking any drugs that could have affected the pain perception. Patients having active pain in more than one tooth were excluded from the study. Teeth with fused roots, radiographic evidence of an extra root, large restorations with overhanging margins, full crowns. Teeth with periodontal diseases and large peri-apical lesions.

Design outcomes

Primary

Measure	Time frame
The aim of this randomized double-blinded clinical study was to evaluate and compare the efficacy of intra-ligamentary injection using articaine, ketorolac and dexamethasone for reduction of endodontic pain in patients with symptomatic irreversible pulpitis in permanent mandibular molars.Timepoint: Outcome for pain reduction will be assessed 5 mins after intervention with the drugs and heart rate will be monitored every minute upto 5 minutes after intervention with the drugs as intraligamenntary injection.	—

Measure

Time frame

The aim of this randomized double-blinded clinical study was to evaluate and compare the efficacy of intra-ligamentary injection using articaine, ketorolac and dexamethasone for reduction of endodontic pain in patients with symptomatic irreversible pulpitis in permanent mandibular molars.Timepoint: Outcome for pain reduction will be assessed 5 mins after intervention with the drugs and heart rate will be monitored every minute upto 5 minutes after intervention with the drugs as intraligamenntary injection.

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Secondary

Measure	Time frame
To evaluate heart rate using finger pulse oximeter.Timepoint: At 15-second intervals until 5 minutes after intra-ligamentary injections. The timer for heart rate measurement started after the end of the distal injections.	—

Countries

India

Contacts

Public ContactSAMALA ANUHYA

KAMINENI INSTITUTE OF DENTAL SCIENCES

drsjayapradareddy@gmail.com9703936020

Outcome results