Health Condition 1: A488- Other specified bacterial diseases
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Nil: Nil
Sponsors
Manipal Academy of Higher Education, Manipal
Eligibility
Inclusion criteria
Inclusion criteria: Adult patients above 18 years admitted to Kasturba hospital Confirmed diagnosis of melioidosis Patients with or without comorbidities
Exclusion criteria
Exclusion criteria: Below 18 years of age Pregnant or breast-feeding Inability to get consent of patient or next of kin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Following vaccination, adaptive immune responses will be measured in mice. Given the intracellular nature of Bps, both T and B cell responses are expected to drive recognition and clearance. CD4+ and CD8+ T cell activity will be assessed alongside B cell activation and antigen-specific antibody production. Lymphocyte expansion will be measured via flow cytometry or ELISPOT. Cytokine profiles will also be analyzed to evaluate adaptive immune function and activation. Timepoint: Baseline, day 14 and day 28 | — |
Secondary
| Measure | Time frame |
|---|---|
| NilTimepoint: Nil | — |
Countries
India
Contacts
Public ContactDr Chiranjay Mukhopadhyay
Kasturba Medical College, Manipal
Outcome results
None listed