Health Condition 1: C119- Malignant neoplasm of nasopharynx,unspecified
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Nil: Nil
Sponsors
Yanpothung Yanthan
Abhinandan Das
Eligibility
Inclusion criteria
Inclusion criteria: Biopsy-proven nasopharyngeal carcinoma. Age 18 to 70 years. Stage II to IVA disease (AJCC 9th edition). ECOG performance status 0 to 1 Eligible for induction chemotherapy followed by concurrent chemoradiation. Capable of providing written or witnessed informed consent
Exclusion criteria
Exclusion criteria: Prior head and neck radiotherapy. Previous head and neck malignancy regardless of interval since diagnosis. Previous Non-Head and Neck malignancy (excluding basal cell carcinoma) with disease free interval less than 10 years. Uncontrolled comorbidities or pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To estimate the 2-year locoregional failure-free survival (LR-FFS) in NPC patients treated using IG-2024 CTV delineation.Timepoint: To estimate the 2-year locoregional failure-free survival (LR-FFS) in NPC patients treated using IG-2024 CTV delineation. | — |
Secondary
| Measure | Time frame |
|---|---|
| To estimate the incidence and severity of acute and late toxicities using CTCAE v6.0Timepoint: Acute till 3 months after treatment completion. Late after 3 months; To analyse dosimetric parameters, including PTV/CTV/GTV coverage and OAR dose metrics.Timepoint: At the time of radiotherapy planning; To compare the estimated 2-year LR-FFS, toxicities, and dosimetric parameters with historical benchmarks based on IG-2018.Timepoint: Acute toxicity till 3 months after treatment completion. Late after 3 months. 2 years LR-FFS | — |
Countries
India
Contacts
Public ContactYanpothung Yanthan
Dr. B. Borooah Cancer Institute
Outcome results
None listed