Health Condition 1: K929- Disease of digestive system, unspecified
Conditions
Interventions
Intervention1: Dexmeditomidine: Dexmedetomidine will be administered intravenously. A loading dose of 1 g/kg will be given over 10 minutes, followed by a continuous intravenous infusion at a rate of
Sponsors
Saptagiri Mypati
Eligibility
Inclusion criteria
Inclusion criteria: Patients aged eighteen to sixty five years of either gender belonging to ASA physical status one or two scheduled for elective abdominal surgery under general anesthesia and willing to provide written informed consent.
Exclusion criteria
Exclusion criteria: Patients with neurological disorders affecting electroencephalogram, chronic use of sedatives or opioids, severe cardiac hepatic or renal disease, known allergy to study drugs, pregnant or lactating women and patients unwilling to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of the study is the correlation between Bispectral Index (BIS) values and clinical depth of sedation assessed using the Ramsay Sedation Scale (RSS) in patients receiving dexmedetomidine or propofol during abdominal surgery under general anesthesia. This primary outcome is used to assess the effect of the intervention and comparator agents on depth of sedation and forms the basis for comparison between the two groups.Timepoint: *Baseline (before induction of anesthesia) *Post-induction *At skin incision *Every 5 minutes intraoperatively *At the end of surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of bispectral index values between dexmedetomidine and propofol groups.Timepoint: Intraoperative period.;Hemodynamic parameters including heart rate and blood pressure.Timepoint: Baseline, intraoperative period and end of surgery.;Recovery profile including time to eye opening extubation and orientation.Timepoint: Postoperative period.;Incidence of adverse events related to study drugs.Timepoint: Intraoperative and postoperative period. | — |
Countries
India
Contacts
Public ContactSaptagiri Mypati
Vinayaka Missions Kirupananda Variyar Medical College & Hospital
Outcome results
None listed