Health Condition 1: I289- Disease of pulmonary vessels, unspecified Health Condition 2: I289- Disease of pulmonary vessels, unspecified
Conditions
Interventions
Intervention1: sepsis patients with RV PA Uncoupling: intervention group-Baseline ECHO will be done within 6 hours of ICU Admission. RVPA Uncoupling will be calculated from TAPSE/ PASP ratio.If the r
Sponsors
Department of Anaesthesiology and Critical care, AIIMS Bhubaneswar
Eligibility
Inclusion criteria
Inclusion criteria: Age more than 18 years Patients suspected or diagnosed with sepsis Admitted to intensive care units
Exclusion criteria
Exclusion criteria: No informed consent Acute coronary syndrome within 1 week Concomitant milrinone and dobutamine therapy at initiation Prosthetic valves or valvular heart diseases Chronic pulmonary hypertension IAP more than 20mmHg
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| To explore the association between lower TAPSE/PASP ratio and clinical outcomes, including ICU mortality and in-hospital mortality. To assess the relationship between RV Injury Score and patient outcomes in sepsis. To compare clinical and echocardiographic responses between responders and non-responders following TAPSE/PASP-guided management. To evaluate changes in TAPSE/PASP ratio over the course of treatment and determine whether these changes correlate with clinical improvementTimepoint: T1- Baseline ECHO within 6 hours. T2-daily followup ECHO till the period of ICU stay | — |
Primary
| Measure | Time frame |
|---|---|
| To evaluate the feasibility of using a non-invasive TAPSE/PASP ratio to guide hemodynamic management of right ventricular dysfunction in patients with sepsis. Timepoint: daily echocardiography will be done and outcome will be assessed daily.final outcome will be measured on the last day of patients ICU stay. | — |
Countries
India
Contacts
Public ContactPrasanta Kumar Das
AIIMS Bhubaneswar
Outcome results
None listed