Health Condition 1: - Health Condition 2: O- Medical and Surgical
Conditions
Interventions
Intervention1: ISOXSUPRINE, PENTOXIFYLLINE, COLCHICINE: Isoxpurine: 100 mg orally, twice a day for 3 months.
Pentoxifylline: 400 mg orally, twice a day for 3 months.
Colchicine: 0.5 mg orally, twic
Sponsors
Preeti Parameswaran Nair
Eligibility
Inclusion criteria
Inclusion criteria: 1 OSMF diagnosed as Grade II clinically- (More C et al classification of OSMF) 2 Adults aged 18 to 65 years diagnosed with oral submucous fibrosis Gd II. 3 Patients who have not received any treatment for oral submucous fibrosis in the last three months. Patients who willing to quit the usage of areca nut and tobacco
Exclusion criteria
Exclusion criteria: 1 Patients with a history of allergic reactions to the study medications. 2 Pregnant or breastfeeding women. 3 Patients with severe systemic diseases or malignancies. 4 Patients with other white or red lesions of the oral mucosa.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Interincisal Opening- measured in millimeters at each visit Pain and burning sensation Assessed using a visual analong scale (VAS) Timepoint: baeline, 1 month, 2 months, 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| NILTimepoint: NIL | — |
Countries
India
Contacts
Public ContactDr Preeti Parameswaran Nair
PEOPLES COLLEGE OF DENTAL SCIENCES AND RESEARCH CENTRE BHOPAL
Outcome results
None listed